1: 99 percent / toluenesulfonic acid monohydrate / benzene / 5 h / Heating
2: benzyltrimethylammonium hydroxide / ethanol / Heating
3: H2, NH3, Raney nickel / ethanol / 2 h / 50 °C / 3040 - 3800 Torr
4: conc. H2SO4 / 1 h / Ambient temperature
5: 71 percent / diethyl ether; 1,2-dichloro-ethane / 1 h
View Scheme
参考文献
Cliffe, Ian A.; Lien, Eric L.; Mansell, Howard L.; Steiner, Kurt E.; Todd, Richard S.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 7 p. 1169 - 1175
Guha; Basu-Mallik
Journal of the Indian Chemical Society, 1934 , vol. 11, p. 395,399
Full Text Show Details
Menon; Perkin; Robinson
Journal of the Chemical Society, 1930 , p. 830,840
1: indole-2,3-dione With CaH2 in N,N-dimethyl-formamide
T=100°C; 1 h;
2: ethyl bromoacetate in N,N-dimethyl-formamide
T=100°C; 4 h;
参考文献
Loetter, Angelique N.C.; Pathak, Rakhi; Sello, Thato S.; Fernandes, Manuel A.; van Otterlo, Willem A.L.; de Koning, Charles B.
Tetrahedron, 2007 , vol. 63, # 10 p. 2263 - 2274