(3S,4S)-3-[(R)-1-(叔丁基二甲基硅氧基)乙基]-4-[(R)-1-羰乙基]-2-氮杂环丁酮合成路线 （共 103 条）
反应条件
lithium hydroxide; dihydrogen peroxide in tetrahydrofuran T=10°C; 1 h;
参考文献
Seki, Masahiko; Kondo, Kazuhiko; Iwasaki, Tameo
Journal of the Chemical Society - Perkin Transactions 1, 1996 , # 23 p. 2851 - 2856
反应条件
1: With lithium hydroxide hydrate; water; dihydrogen peroxide in tetrahydrofuran T=0°C; 1 h; 2: With sodium sulfite in tetrahydrofuran; water 3: With hydrogenchloride in water
参考文献
WO2010/49233 A1, ;
Page/Page column 15 ;
反应条件
hydrogen; palladium on activated charcoal in ethyl acetate 4 h;
参考文献
Ito; Terashima
Tetrahedron Letters, 1987 , vol. 28, # 52 p. 6625-6628
反应条件
lithium hydroxide; dihydrogen peroxide in tetrahydrofuran T=0°C; 1 h;
参考文献
Journal of Organic Chemistry, , vol. 62, # 9 p. 2877 - 2884
反应条件
sodium hydroxide in water; tert-butyl alcohol 72 h; Ambient temperature;
参考文献
Ito; Terashima
Tetrahedron Letters, 1987 , vol. 28, # 52 p. 6625-6628
反应条件
hydrogen; Rult;(R)-2,2'-bis(diphenylphosphino)-1,1'-binaphthylgt;(OCOCH3)2 in methanol T=15 - 30°C; P=76000.1 Torr; 12 h; Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 52, # 14 p. 3174 - 3176
反应条件
1.1: LiHMDS / tetrahydrofuran; hexane / 0.5 h / -78 °C 1.2: tetrahydrofuran; hexane / 2 h / -78 °C 2.1: 82 percent / aq. LiOH; H2O2 / methanol / 20 h / 20 °C View Scheme
参考文献
Heterocycles, , vol. 72, p. 103 - 110
反应条件
1: imidazole / dimethylformamide / Ambient temperature 2: 1.) lithium diisopropylamide, HMPA / 1.) THF, hexane, -78 deg C, 40 min, 2.) THF, hexane, -78 deg C, 1.5 h 3: 1.) lithium diisopropylamide, HMPA, 2.) acetic acid / 1.) THF, hexane, -78 deg C, 0.5 h, 2.) THF, hexane, -78 deg C, 5 min 4: 83 percent / NaOH / methanol; H2O / 1.) RT, 0.5 h, 2.) 50 deg C, 1 h View Scheme
参考文献
Heterocycles, , vol. 21, # 1 p. 29 - 40
反应条件
silica gel; ozone in dichloromethane T=-78 - 20°C;
参考文献
Lee, You-Sang; Choung, Won-Keun; Kim, Kyoung Hoon; Kang, Tae Won; Ha, Deok-Chan
Tetrahedron, 2004 , vol. 60, # 4 p. 867 - 870
反应条件
lithium hydroxide; dihydrogen peroxide in methanol T=20°C; 20 h;
参考文献
Heterocycles, , vol. 72, p. 103 - 110
