4-甲氧基吲哚-3-甲醛合成路线 （共 29 条）
反应条件
1.1: 6.8 g / NBS / tetrahydrofuran; hexane / 3 h / -78 °C 2.1: t-BuLi / pentane; tetrahydrofuran / 0.17 h / -78 °C 2.2: 54 percent / pentane; tetrahydrofuran / 0.25 h / -78 °C 3.1: 85 percent / Bu4NF / tetrahydrofuran / 0.17 h / 20 °C View Scheme
参考文献
Synthesis, , # 2 p. 267 - 275
反应条件
1.1: t-BuLi / pentane; tetrahydrofuran / 0.17 h / -78 °C 1.2: 54 percent / pentane; tetrahydrofuran / 0.25 h / -78 °C 2.1: 85 percent / Bu4NF / tetrahydrofuran / 0.17 h / 20 °C View Scheme
参考文献
Synthesis, , # 2 p. 267 - 275
反应条件
1: 99.6 percent / POCl3 / 9 h / 25 °C 2: 83.2 percent / CuI / dimethylformamide; methanol / 0.5 h / 110 - 120 °C View Scheme
参考文献
Heterocycles, , vol. 22, # 4 p. 797 - 801
反应条件
1: 94 percent / Cu; quinoline / 2 h / Heating 2: 85 percent / phosphoryl chloride / 1.5 h / 0 - 40 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 25 p. 6270 - 6282
反应条件
1: 99 percent / aq. NaOH / 0.5 h / Heating 2: 94 percent / Cu; quinoline / 2 h / Heating 3: 85 percent / phosphoryl chloride / 1.5 h / 0 - 40 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 25 p. 6270 - 6282
反应条件
1.1: potassium carbonate / acetone / 42 h / |Reflux; |Inert atmosphere 2.1: triphenylphosphine; N-chloro-succinimide / tetrahydrofuran / 1 h / |Inert atmosphere; |Reflux 2.2: 1 h / |Reflux View Scheme
参考文献
Chemical Communications, , vol. 48, # 100 p. 12243 - 12245
反应条件
1.1: trichlorophosphate / 0 - 20 °C 2.1: Tl(OCOCF3)3; trifluoroacetic acid / 3 h / 30 °C 2.2: 1 h / 25 °C 2.3: 1 h / 110 °C View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 11, # 7 p. 1149 - 1166
反应条件
sodium tetrahydroborate in methanol; formamide T=100°C; 5 h;
参考文献
Yamada, Fumio; Hashizume, Tomoko; Somei, Masanori
Heterocycles, 1998 , vol. 47, # 1 p. 509 - 516
反应条件
1: 57 percent / NaBH4, dimethylamine / H2O / 2 h / Ambient temperature 2: 86 percent / dimethylformamide; H2O / 1 h / Heating View Scheme
参考文献
Pedras, M. Soledade C.; Yaya, Estifanos E.
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 7 p. 1149 - 1166
反应条件
1: ammonium acetate / 1 h / |Reflux; |Inert atmosphere 2: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C / |Inert atmosphere; |Reflux View Scheme
参考文献
Kerschgens, Isabel P.; Claveau, Elise; Wanner, Martin J.; Ingemann, Steen; Van Maarseveen, Jan H.; Hiemstra, Henk
Chemical Communications, 2012 , vol. 48, # 100 p. 12243 - 12245
