(R)-2-羟基-4-苯基丁酸乙酯合成路线 （共 57 条）
反应条件
1: 1) LDA / 1) THF, -55 deg C 2: 82 percent / xylene / 0.25 h / Heating 3: 1) O3, 2) Me2S / 1) -65 deg C, 2) r.t., 1h View Scheme
参考文献
Tetrahedron Letters, , vol. 31, # 25 p. 3567 - 3570
反应条件
1: 88 percent / diisobutylaluminum hydride / diethyl ether / -60 °C 2: 82 percent / xylene / 0.25 h / Heating 3: 1) O3, 2) Me2S / 1) -65 deg C, 2) r.t., 1h View Scheme
参考文献
Tetrahedron Letters, , vol. 31, # 25 p. 3567 - 3570
反应条件
1: 80 percent / Swern oxidation 2: 88 percent / diisobutylaluminum hydride / diethyl ether / -60 °C 3: 82 percent / xylene / 0.25 h / Heating 4: 1) O3, 2) Me2S / 1) -65 deg C, 2) r.t., 1h View Scheme
参考文献
Tetrahedron Letters, , vol. 31, # 25 p. 3567 - 3570
反应条件
hydrogenchloride; [RuCl(benzene){(2,2,2',2'-tetramethyl[4,4'-bibenzo[d][1,3]dioxole]-5,5'-diyl)bis(diphenylphosphine)}]Cl; water; hydrogen T=90°C; P=20686.5 Torr; 20 h; Autoclave; optical yield given as percent eeenantioselective reaction;
参考文献
Journal of Organic Chemistry, , vol. 75, # 17 p. 6027 - 6030
反应条件
1: 95 percent / H2SO4 / 2 h / Heating 2: 100 percent / pyridine / CH2Cl2 / 20 °C 3: ethanol / 48 h / Heating 4: 3.6 g / K2CO3 / ethanol / 20 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 12, # 11 p. 1583 - 1587
反应条件
1: 100 percent / pyridine / CH2Cl2 / 20 °C 2: ethanol / 48 h / Heating 3: 3.6 g / K2CO3 / ethanol / 20 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 12, # 11 p. 1583 - 1587
反应条件
1: ethanol / 48 h / Heating 2: 3.6 g / K2CO3 / ethanol / 20 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 12, # 11 p. 1583 - 1587
反应条件
2: 97 percent / HCl (g) / ethanol View Scheme
参考文献
Tetrahedron Letters, , vol. 29, # 4 p. 423-426
反应条件
1: 82 percent / xylene / 0.25 h / Heating 2: 1) O3, 2) Me2S / 1) -65 deg C, 2) r.t., 1h View Scheme
参考文献
Tetrahedron Letters, , vol. 31, # 25 p. 3567 - 3570
反应条件
1: 99.3 percent / NH4Cl / aq. NH3 / 50 h / 37 °C / enzymatic hydrolysis with Pseudomonas putida at pH 9 2: 89 percent / NaNO2, 2N H2SO4, 4N H2SO4 / aq. acetic acid / 24 h, r.t.; 3 h, 100 deg C 3: 65 percent / SOCl2 / 24 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 37, # 2 p. 280 - 283
