2,6-二甲基-1H-吡啶-4-硫酮合成路线 （共 10 条）
反应条件
sodium hydrogensulfide in N,N-dimethyl-formamide
T=140°C;
参考文献
Yoakim; Bonneau; Deziel; Doyon; Duan; Guse; Landry; Malenfant; Naud; Ogilvie; O'Meara; Plante; Simoneau; Thavonekham; Boes; Cordingley
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 3 p. 739 - 742
反应条件
1: With lithium diisopropyl amide in tetrahydrofuran
T=-80°C; 1 h; Inert atmosphere;
2: With sulfur in tetrahydrofuran
T=-80 - 20°C; 1.5 h; Inert atmosphere;
参考文献
Bach, Peter; Marczynke, Michaela; Giordanetto, Fabrizio
European Journal of Organic Chemistry, 2012 , # 35 p. 6940 - 6952
反应条件
1: 85 percent / mCPBA / CH2Cl2
2: 59 percent / HNO3; H2SO4 / 80 °C
3: 86 percent / aq. HCl / 200 °C
4: 100 percent / PCl3 / CHCl3
5: 52 percent / NaSH / dimethylformamide / 140 °C
View Scheme
参考文献
Yoakim; Bonneau; Deziel; Doyon; Duan; Guse; Landry; Malenfant; Naud; Ogilvie; O'Meara; Plante; Simoneau; Thavonekham; Boes; Cordingley
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 3 p. 739 - 742
反应条件
1: 59 percent / HNO3; H2SO4 / 80 °C
2: 86 percent / aq. HCl / 200 °C
3: 100 percent / PCl3 / CHCl3
4: 52 percent / NaSH / dimethylformamide / 140 °C
View Scheme
参考文献
Yoakim; Bonneau; Deziel; Doyon; Duan; Guse; Landry; Malenfant; Naud; Ogilvie; O'Meara; Plante; Simoneau; Thavonekham; Boes; Cordingley
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 3 p. 739 - 742
反应条件
1: 86 percent / aq. HCl / 200 °C
2: 100 percent / PCl3 / CHCl3
3: 52 percent / NaSH / dimethylformamide / 140 °C
View Scheme
参考文献
Yoakim; Bonneau; Deziel; Doyon; Duan; Guse; Landry; Malenfant; Naud; Ogilvie; O'Meara; Plante; Simoneau; Thavonekham; Boes; Cordingley
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 3 p. 739 - 742
反应条件
1: 100 percent / PCl3 / CHCl3
2: 52 percent / NaSH / dimethylformamide / 140 °C
View Scheme
参考文献
Yoakim; Bonneau; Deziel; Doyon; Duan; Guse; Landry; Malenfant; Naud; Ogilvie; O'Meara; Plante; Simoneau; Thavonekham; Boes; Cordingley
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 3 p. 739 - 742
反应条件
pyridine; diphosphorus pentasulfide
参考文献
Ochiai; Fujimoto
Pharmaceutical Bulletin, 1954 , vol. 2, p. 131,136
参考文献
Marckwald; Klemm; Trabert
Chemische Berichte, 1900 , vol. 33, p. 1556
参考文献
Woods
Texas J. Sci., 1959 , vol. 11, p. 28,29
参考文献
Marckwald; Klemm; Trabert
Chemische Berichte, 1900 , vol. 33, p. 1556
