(4-溴-1H-吲哚-3-基)乙腈合成路线 （共 9 条）
反应条件
sodium hydroxide in methanol 2 h; Heating;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 33, # 9 p. 3696 - 3708
反应条件
1: 4-bromo-1H-indole; formaldehyd With dimethyl amine
2: potassium cyanide in water; N,N-dimethyl-formamide
Further stages.;
参考文献
Liras; Lynch; Fryer; Vu; Martin
Journal of the American Chemical Society, 2001 , vol. 123, # 25 p. 5918 - 5924
反应条件
1: 4-bromo-1H-indole; formaldehyd With dimethyl amine in acetic acid
T=20°C; 20 h;
2: sodium cyanide in water; N,N-dimethyl-formamide
2 h; Heating;
参考文献
Kalinin, Alexey V.; Chauder, Brian A.; Rakhit, Suman; Snieckus, Victor
Organic Letters, 2003 , vol. 5, # 19 p. 3519 - 3521
反应条件
1: AcOH / H2O / 0 - 25 °C
2: dimethylformamide; H2O / 2 h / 140 °C
View Scheme
参考文献
Martin; Liras
Journal of the American Chemical Society, 1993 , vol. 115, # 22 p. 10450 - 10451
反应条件
in water; N,N-dimethyl-formamide
1 h; Heating;
参考文献
Somei; Kizu; Kunimoto; Yamada
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 9 p. 3696 - 3708
反应条件
tetrabutyl ammonium fluoride
参考文献
Iwao, Masatomo; Motoi, Osamu
Tetrahedron Letters, 1995 , vol. 36, # 33 p. 5929 - 5932
反应条件
1: 1.) TTFA, 2.) CuBr2 / 1.) TFA, room temp., 2 h; 2.) DMF, 120 deg C, 1 h
2: 60.5 percent / 40percent NaOH / methanol / 1.5 h / Heating
3: 96.3 percent / H2O; acetic acid / 48 h / Ambient temperature
4: 89.1 percent / dimethylformamide; H2O / 1 h / Heating
View Scheme
参考文献
Somei; Kizu; Kunimoto; Yamada
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 9 p. 3696 - 3708
反应条件
1: 88.5 percent / 40percent aq. NaOH / methanol / 1 h / Heating
2: 96.3 percent / H2O; acetic acid / 48 h / Ambient temperature
3: 89.1 percent / dimethylformamide; H2O / 1 h / Heating
View Scheme
参考文献
Somei; Kizu; Kunimoto; Yamada
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 9 p. 3696 - 3708
反应条件
1: 60.5 percent / 40percent NaOH / methanol / 1.5 h / Heating
2: 96.3 percent / H2O; acetic acid / 48 h / Ambient temperature
3: 89.1 percent / dimethylformamide; H2O / 1 h / Heating
View Scheme
参考文献
Somei; Kizu; Kunimoto; Yamada
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 9 p. 3696 - 3708
