芴甲氧羰酰基-6-氨基己酸合成路线 （共 8 条）
反应条件
sodium carbonate in 1,4-dioxane; water T=20°C; 18 h;
参考文献
Khandazhinskaya; Kukhanova; Jasko
Russian Journal of Bioorganic Chemistry, 2005 , vol. 31, # 4 p. 352 - 356
反应条件
sodium hydrogencarbonate in water; acetone Acylation; 3 h;
参考文献
Wojczewski, Christian; Schwarzer, Karin; Engels, Joachim W.
Helvetica Chimica Acta, 2000 , vol. 83, # 6 p. 1268 - 1277
反应条件
in N,N-dimethyl-formamide 1 h; Ambient temperature;
参考文献
Wasner, Marita; Suhadolnik, Robert J.; Horvath, Susan E.; Adelson, Martin E.; Kon, Ning; Guan, Ming-Xu; Henderson, Earl E.; Pfleiderer, Wolfgang
Helvetica Chimica Acta, 1997 , vol. 80, # 4 p. 1061 - 1072
反应条件
naphthalene; sodium in tetrahydrofuran T=20°C; 0.5 h;
参考文献
Chemical Communications, , # 48 p. 5146 - 5148
反应条件
piperidine in N,N-dimethyl-formamide
参考文献
Udugamasooriya, D. Gomika; Dunham, Geoff; Ritchie, Caroline; Brekken, Rolf A.; Kodadek, Thomas
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 22 p. 5892 - 5894
反应条件
triethylsilane 1.) TFA, CHCl3, H2O, 30 min, 2.) TFA, CHCl3, H2O; Yield given. Multistep reaction;
参考文献
Luke, Richard W. A.; Boyce, Patrick G. T.; Dorling, E. Kate
Tetrahedron Letters, 1996 , vol. 37, # 2 p. 263 - 266
反应条件
dicyclohexyl-carbodiimide in tetrahydrofuran
T=0 - 20°C;
参考文献
PFIZER INC.; DIRICO, Kenneth John; EUSTAQUIO, Alessandra S.; GREEN, Michael Eric; HE, Haiyin; HE, Min; KOEHN, Frank Erich; O'DONNELL, Christopher John; PUTHENVEETIL, Sujiet; RATNAYAKE, Anokha Sayani; SUBRAMANYAM, Chakrapani; TESKE, Jesse Alexander; YANG, Hui Yu
Patent: WO2014/68443 A1, 2014 ;
Location in patent: Page/Page column 197; 198 ;
反应条件
1: With 4-methyl-morpholine; isobutyl chloroformate in tetrahydrofuran
T=-78 - 0°C; 0.666667 h;
2: With sodium tetrahydroborate in tetrahydrofuran; methanol
T=-78 - 20°C; Further stages.;
参考文献
Quintanar-Audelo, Martina; Fernandez-Carvajal, Asia; Van Den Nest, Wim; Carreno, Cristina; Ferrer-Montiel, Antonio; Albericio, Fernando
Journal of Medicinal Chemistry, 2007 , vol. 50, # 24 p. 6133 - 6143
