N-(4-乙氧基-2-硝基苯基)乙酰胺合成路线 （共 19 条）
反应条件
1: conc. HCl / 2 h / Heating 2: pyridine / 2.5 h / 100 °C 3: Na, ethanol / 4 h / Heating 4: 2 h / Heating 5: aq. hydrazine / Raney-nickel / ethanol / 70 - 80 °C 6: aq. HCl / 2 h / Heating View Scheme
参考文献
Korolev, B. A.; Osmolovskaya, L. A.; Kuznetsov, Yu. V.; Stolyarova, L. G.; Smirnov, L. D.
Bull. Russ. Acad. Sci. Div. Chem. Sci. (Engl. Transl.), 1992 , vol. 41, # 2 p. 421 - 425,333 - 336
反应条件
methanol; sodium hydride in tetrahydrofuran T=20°C; 6 h;
参考文献
LG LIFE SCIENCES LTD.
Patent: WO2009/82152 A2, 2009 ;
Location in patent: Page/Page column 72 ;
WO 2009/082152 A2
参考文献
Reverdin
Recueil des Travaux Chimiques des Pays-Bas, 1929 , vol. 48, p. 839
反应条件
hydrogen; palladium on activated charcoal in ethyl acetate
参考文献
Murray, Michael; Ryan, Adrian J.; Little, Peter J.
Journal of Medicinal Chemistry, 1982 , vol. 25, # 8 p. 887 - 892
反应条件
1: acetic acid; aqueous sodium chlorate / anschliessendes Behandeln mit rauchender Salzsaeure unter Kuehlung 2: ethanolic KOH-solution 3: concentrated H2SO4 / Diazotization.Erwaermen der Diazoniumsalz-Loesung mit Aethanol 4: H2SO4 View Scheme
参考文献
van Erp
Journal fuer Praktische Chemie (Leipzig), 1931 , vol. <2> 129, p. 327,335
反应条件
1: conc. HCl / 2 h / Heating 2: aq. hydrazine / Raney nickel / 5 h / 60 - 70 °C View Scheme
参考文献
Rtishchev; Selitrennikov
Russian Journal of General Chemistry, 2004 , vol. 74, # 3 p. 428 - 437
反应条件
nitric acid; acetic acid
T=70°C; 0.166667 h;
参考文献
Murray, Michael; Ryan, Adrian J.; Little, Peter J.
Journal of Medicinal Chemistry, 1982 , vol. 25, # 8 p. 887 - 892
反应条件
nitric acid; acetic acid
T=0°C;
参考文献
Macciotta; Deffenu
Atti V.Congr.naz.Chim.pura appl.Sardinien, 1935 , p. 389,392
参考文献
van Erp
Journal fuer Praktische Chemie (Leipzig), 1931 , vol. <2> 129, p. 327,335
反应条件
nitric acid; acetic acid
参考文献
Demers; Lynn
Journal of the American Pharmaceutical Association (1912-1977), 1941 , vol. 30, p. 627
