(R)-4-氯-3-羟基丁酸甲酯合成路线

32807-28-64-氯乙酰乙酸甲酯→88496-70-2(R)-4-氯-3-羟基丁酸甲酯+86728-93-0(S)-4-氯-3-羟基丁酸甲酯

参考文献

Ushio, Kazutoshi; Inouye, Kiyoko; Nakamura, Kaoru; Oka, Shinzaburo; Ohno, Atsuyoshi
Tetrahedron Letters, 1986 , vol. 27, # 23 p. 2657 - 2660

114819-45-3→88496-70-2(R)-4-氯-3-羟基丁酸甲酯

参考文献

VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2007/21982 A2, 2007 ;
Location in patent: Page/Page column 67-68 ;

32807-28-64-氯乙酰乙酸甲酯→88496-70-2(R)-4-氯-3-羟基丁酸甲酯

参考文献

Bizerra, Ayla M.C.; Gonzalo, Gonzalo de; Lavandera, Ivan; Gotor-Fernandez, Vicente; de Mattos, Marcos Carlos; de Oliveira, Maria da Conceicao F.; Lemos, Telma L.G.; Gotor, Vicente
Tetrahedron Asymmetry, 2010 , vol. 21, # 5 p. 566 - 570

10488-68-34-氯-3-羟基丁酸甲酯+143-33-9氰化钠→88496-70-2(R)-4-氯-3-羟基丁酸甲酯+86728-93-0(S)-4-氯-3-羟基丁酸甲酯+150966-86-2

参考文献

Elenkov, Maja Majeric; Tang, Lixia; Hauer, Bernhard; Janssen, Dick B.
Organic Letters, 2006 , vol. 8, # 19 p. 4227 - 4229

4128-31-8仲辛醇+32807-28-64-氯乙酰乙酸甲酯→5978-70-1(R)-(-)-2-辛醇+88496-70-2(R)-4-氯-3-羟基丁酸甲酯

参考文献

Journal of Organic Chemistry, , vol. 74, # 4 p. 1730 - 1732

773837-37-9+32807-28-64-氯乙酰乙酸甲酯→88496-70-2(R)-4-氯-3-羟基丁酸甲酯+150966-86-2

参考文献

European Journal of Organic Chemistry, , # 14 p. 2293 - 2298

10488-68-34-氯-3-羟基丁酸甲酯→58081-05-3(R)-3-羟基-gamma-丁内酯+88496-70-2(R)-4-氯-3-羟基丁酸甲酯+5469-16-9(±)-3-羟基-r-丁内酯

参考文献

Advanced Synthesis and Catalysis, , vol. 345, # 4 p. 437 - 455

32807-28-64-氯乙酰乙酸甲酯→88496-70-2(R)-4-氯-3-羟基丁酸甲酯+109462-42-2

参考文献

Tetrahedron Asymmetry, , vol. 20, # 4 p. 483 - 488

4509-09-53,4-环氧丁酸甲酯+143-33-9氰化钠→88496-70-2(R)-4-氯-3-羟基丁酸甲酯+86728-93-0(S)-4-氯-3-羟基丁酸甲酯+141942-84-9(3R)-4-氰基-3-羟基丁酸甲酯+150966-86-2

参考文献

Organic Letters, , vol. 8, # 19 p. 4227 - 4229

10488-68-34-氯-3-羟基丁酸甲酯→88496-70-2(R)-4-氯-3-羟基丁酸甲酯

参考文献

Tetrahedron Asymmetry, , vol. 7, # 11 p. 3109 - 3112