2-苯基-1-(1-哌嗪基)乙酮合成路线 （共 10 条）
反应条件
lithium aluminium tetrahydride in diethyl ether T=20°C; Yield given;
参考文献
Wieringa, J.; Meerendonk, A. van den; Steenvoorden, J.; Heeres, G.; Bakel, F. van; et al.
Recueil des Travaux Chimiques des Pays-Bas, 1993 , vol. 112, # 2 p. 143 - 150
反应条件
trifluoroacetic acid in dichloromethane
T=20°C; 0.5 h;
参考文献
Gessier, Francois; Preuss, Inga; Yin, Hong; Rosenkilde, Mette M.; Laurent, Stephane; Endres, Ralf; Chen, Yu A.; Marsilje, Thomas H.; Seuwen, Klaus; Nguyen, Deborah G.; Sailer, Andreas W.
Journal of Medicinal Chemistry, 2014 , vol. 57, # 8 p. 3358 - 3368
反应条件
water in N,N-dimethyl-formamide
T=100°C; 16 h;
参考文献
Shen, Wang; Kunzer, Aaron
Organic letters, 2002 , vol. 4, # 8 p. 1315 - 1317
反应条件
acetic acid
T=60°C; 0.0666667 h; SonicationIrradiation;
参考文献
Maurya, Ram Awatar; Hoang, Phan Huy; Kim, Dong-Pyo
Lab on a Chip - Miniaturisation for Chemistry and Biology, 2012 , vol. 12, # 1 p. 65 - 68
反应条件
1: phenylacetic acid With benzotriazol-1-ol; dicyclohexyl-carbodiimide in chloroform; N,N-dimethyl-formamide
T=20°C; Acylation; 0.5 h;
2: piperazine in chloroform; N,N-dimethyl-formamide
T=20°C; Acylation; 2 h;
参考文献
Alexopoulos, Kostas; Fatseas, Panagiotis; Melissari, Efi; Vlahakos, Demetrios; Smith, Julian; Mavromoustakos, Thomas; Saifeddine, Mahmoud; Moore, Graham; Hollenberg, Morley; Matsoukas, John
Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 6 p. 1033 - 1041
参考文献
Development Center for Biotechnology
Patent: US6313293 B1, 2001 ;
反应条件
1: piperazine With 9-borabicyclo[3.3.1]nonane dimer in tetrahydrofuran; hexane
T=20°C; 1 h;
2: phenylacetyl chloride in tetrahydrofuran; hexane
T=20°C; 2 h;
参考文献
Zhang, Zhongxing; Yin, Zhiwei; Meanwell, Nicholas A.; Kadow, John F.; Wang, Tao
Organic Letters, 2003 , vol. 5, # 19 p. 3399 - 3402
反应条件
1: pyridine / dichloromethane / 1.5 h / 0 - 20 °C
2: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C
View Scheme
参考文献
Gessier, Francois; Preuss, Inga; Yin, Hong; Rosenkilde, Mette M.; Laurent, Stephane; Endres, Ralf; Chen, Yu A.; Marsilje, Thomas H.; Seuwen, Klaus; Nguyen, Deborah G.; Sailer, Andreas W.
Journal of Medicinal Chemistry, 2014 , vol. 57, # 8 p. 3358 - 3368
反应条件
1: piperazine; piperazine Dihydrochloride in water
0.0833333 h;
2: phenylacetyl imidazol amide With sodium chloride in water
0.5 h;
3: With sodium hydroxide in water
chemoselective reaction;
参考文献
Verma, Sanjeev K.; Ghorpade, Ramarao; Pratap, Ajay; Kaushik
Green Chemistry, 2012 , vol. 14, # 2 p. 326 - 329
反应条件
1.1: 0.08 h / 20 °C / Neat (no solvent)
2.1: water / 0.08 h
2.2: 0.5 h
View Scheme
参考文献
Verma, Sanjeev K.; Ghorpade, Ramarao; Pratap, Ajay; Kaushik
Green Chemistry, 2012 , vol. 14, # 2 p. 326 - 329
