2-甲基-6-三氟甲基苯胺合成路线 （共 10 条）
反应条件
hydrogen; palladium 10 on activated carbon in methanol T=20°C; P=2250.23 Torr;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2006/100009 A1, 2006 ;
Location in patent: Page/Page column 132 ;
WO 2006/100009 A1
反应条件
hydrogen; palladium on activated charcoal in water T=50°C; P=3102.9 Torr; 3 h;
参考文献
Chupp, John P.; Balthazor, Terry M.; Miller, Michael J.; Pozzo, Mark J.
Journal of Organic Chemistry, 1984 , vol. 49, p. 4711 - 4716
反应条件
nickel in ethanol 1 h; Ambient temperature;
参考文献
Chupp, John P.; Balthazor, Terry M.; Miller, Michael J.; Pozzo, Mark J.
Journal of Organic Chemistry, 1984 , vol. 49, p. 4711 - 4716
反应条件
1: 86.9 percent / 40percent peracetic acid / CH2Cl2 / 0 °C 2: 90 percent / HCl gas / 1,2-dichloro-ethane / 5 h / 50 °C 3: 55 percent / H2, triethylamine / 5percent Pd/C / ethyl acetate / 2 h / 20 - 50 °C / 2585.7 Torr View Scheme
参考文献
Journal of Organic Chemistry, , vol. 49, p. 4711 - 4716
反应条件
2-picoline; Na2S2O5; sulfur dioxide; zinc in N,N-dimethyl-formamide T=20°C; P=2250.2 - 3750.3 Torr; 2 h;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 8 p. 2293 - 2299
反应条件
1: 70 percent / N-chlorosuccinimide, triethylamine / CH2Cl2 / Heating 2: 86.9 percent / 40percent peracetic acid / CH2Cl2 / 0 °C 3: 90 percent / HCl gas / 1,2-dichloro-ethane / 5 h / 50 °C 4: 55 percent / H2, triethylamine / 5percent Pd/C / ethyl acetate / 2 h / 20 - 50 °C / 2585.7 Torr View Scheme
参考文献
Journal of Organic Chemistry, , vol. 49, p. 4711 - 4716
反应条件
1: 90 percent / HCl gas / 1,2-dichloro-ethane / 5 h / 50 °C 2: 55 percent / H2, triethylamine / 5percent Pd/C / ethyl acetate / 2 h / 20 - 50 °C / 2585.7 Torr View Scheme
参考文献
Journal of Organic Chemistry, , vol. 49, p. 4711 - 4716
反应条件
1: 42 percent Chromat. / 90percent HNO3 / 0.25 h / 0 - 5 °C 2: 95 percent / H2 / Raney Ni / ethanol / 24 h / 2585.7 Torr / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 51, # 20 p. 3903 - 3904
反应条件
1: SF4 2: H2 / Raney-Ni / methanol View Scheme
参考文献
AT341509DE2405479 , ;
Chem.Abstr., , vol. 81, # 151817
反应条件
1.1: N-bromosuccinmide / acetonitrile / 1.5 h 2.1: potassium acetate; acetic acid / toluene / 0.25 h 2.2: 18 h / 20 °C View Scheme
参考文献
Pfizer Inc
Patent: US2012/108619 A1, 2012 ;
