[1,2,4]噻唑并[1,5-a]吡嗪-2-胺合成路线 （共 9 条）
反应条件
PPA
T=210°C; 0.833333 h;
参考文献
Vercek, Bojan; Ogorevc, Bozidar,; Stanovnik, Branko; Tisler, Miha
Monatshefte fuer Chemie, 1983 , vol. 114, p. 789 - 798
反应条件
hydroxylamine in ethanol
9 h; Ambient temperature;
参考文献
Vercek, Bojan; Ogorevc, Bozidar,; Stanovnik, Branko; Tisler, Miha
Monatshefte fuer Chemie, 1983 , vol. 114, p. 789 - 798
反应条件
PPA
T=90 - 100°C; 2.5 h;
参考文献
Vercek, Bojan; Ogorevc, Bozidar,; Stanovnik, Branko; Tisler, Miha
Monatshefte fuer Chemie, 1983 , vol. 114, p. 789 - 798
反应条件
1: in 1,4-dioxane
T=20°C; 12 h;
2: With hydroxylamine hydrochloride; triethylamine in methanol; ethanol
T=20°C; 2 h;
3: in methanol; ethanol
4 h; Reflux;
参考文献
Cao, Xufeng; Sun, Zhaoshuan; Cao, Yongbing; Wang, Ruilian; Cai, Tongkai; Chu, Wenjing; Hu, Wenhao; Yang, Yushe
Journal of Medicinal Chemistry, 2014 , vol. 57, # 9 p. 3687 - 3706
反应条件
1: 53 percent / free hydroxylamine / ethanol / 9 h / Ambient temperature
2: 18 percent / H2O / 2 h / Heating
View Scheme
参考文献
Vercek, Bojan; Ogorevc, Bozidar,; Stanovnik, Branko; Tisler, Miha
Monatshefte fuer Chemie, 1983 , vol. 114, p. 789 - 798
反应条件
1: 43 percent / free hydroxylamine / methanol / 54 h / Ambient temperature
2: 19 percent / polyphosphoric acid / 2.5 h / 90 - 100 °C
View Scheme
参考文献
Vercek, Bojan; Ogorevc, Bozidar,; Stanovnik, Branko; Tisler, Miha
Monatshefte fuer Chemie, 1983 , vol. 114, p. 789 - 798
参考文献
Vercek, Bojan; Ogorevc, Bozidar,; Stanovnik, Branko; Tisler, Miha
Monatshefte fuer Chemie, 1983 , vol. 114, p. 789 - 798
反应条件
in water
2 h; Heating;
参考文献
Vercek, Bojan; Ogorevc, Bozidar,; Stanovnik, Branko; Tisler, Miha
Monatshefte fuer Chemie, 1983 , vol. 114, p. 789 - 798
反应条件
in toluene
1 h; Heating;
参考文献
Vercek, Bojan; Ogorevc, Bozidar,; Stanovnik, Branko; Tisler, Miha
Monatshefte fuer Chemie, 1983 , vol. 114, p. 789 - 798
