2,4,6-三甲基苯胺合成路线 (共 254 条)
反应条件
1,3-bis[4-(octadecyloxy)-2,6-diisopropylphenyl]imidazol-2-ylidenyl(3-chloropyridine)PdCl2; potassium tert-butylate in tetrahydrofuran
T=50°C; Buchwald-Hartwig Coupling; 0.5 h; Sealed tube;
参考文献
Krinsky, Jamin L.; Martinez, Alberto; Godard, Cyril; Castillon, Sergio; Claver, Carmen
Advanced Synthesis and Catalysis, 2014 , vol. 356, # 2-3 p. 460 - 474
反应条件
C16H34ClPPd; sodium t-butanolate in toluene
T=50°C; Buchwald-Hartwig amination;
参考文献
Hill, Lensey L.; Crowell, Jason L.; Tutwiler, Strudwick L.; Massie, Nicholas L.; Hines, C. Corey; Griffin, Scott T.; Rogers, Robin D.; Shaughnessy, Kevin H.; Grasa, Gabriela A.; Johansson Seechurn, Carin C. C.; Li, Hongbo; Colacot, Thomas J.; Chou, Joe; Woltermann, Christopher J.
Journal of Organic Chemistry, 2010 , vol. 75, # 19 p. 6477 - 6488
反应条件
hydrogenchloride
Diazotization.Behandlung der Diazoniumsalz-Loesung mit Benzol in Gegenwart von MgSO4 bei 0grad bis 5grad und Versetzen des Reaktionsgemisches mit konz. wss. NaOH;
参考文献
Hey
Journal of the Chemical Society, 1932 , p. 2636,2638
反应条件
thionyl chloride; benzene
参考文献
van Woerden,H.F.; Bijl-Vlieger,S.H.
Recueil des Travaux Chimiques des Pays-Bas, 1974 , vol. 93, p. 85 - 90
参考文献
Michaelis
Justus Liebigs Annalen der Chemie, 1893 , vol. 274, p. 240
反应条件
hydrogenchloride; 2,3-dicyano-5,6-dichloro-p-benzoquinone in water
T=20°C; 2 h; regiospecific reaction;
参考文献
Mane, Madhav S.; Balaskar, Ravi S.; Gavade, Sandip N.; Pabrekar, Pramod N.; Shingare, Murlidhar S.; Mane, Dhananjay V.
Chinese Chemical Letters, 2011 , vol. 22, # 9 p. 1039 - 1042
反应条件
(i) NaNO2, aq. H2SO4, (ii) /BRN= 3594799/, FeCl3; Multistep reaction;
参考文献
Bacon,R.G.R.; Guy,R.G.
Journal of the Chemical Society, 1961 , p. 2428 - 2436
反应条件
1: dichloromethane / 2 h / Reflux
2: sodium acetate; acetic anhydride / Reflux
View Scheme
参考文献
Salewska, Natalia; Boros-Majewska, Joanna; Lcka, Izabela; Chylinska, Katarzyna; Sabisz, Michal; Milewski, Slawomir; Milewska, Maria J.
Journal of Enzyme Inhibition and Medicinal Chemistry, 2012 , vol. 27, # 1 p. 117 - 124
反应条件
ammonium acetate in toluene
参考文献
Neurogen Corporation
Patent: US6291473 B1, 2001 ;
US 6291473 B1
Title/Abstract Full Text Show Details
Neurogen Corporation
Patent: US6472402 B1, 2002 ;
US 6472402 B1
反应条件
4-(N,N-dimethlyamino)pyridine in acetonitrile
T=82°C; 15 h;
参考文献
Knoelker, Hans-Joachim; Braxmeier, Tobias
Tetrahedron Letters, 1996 , vol. 37, # 33 p. 5861 - 5864