3-氟-4-甲基苯甲酸甲酯合成路线 （共 13 条）
反应条件
chloro-trimethyl-silane in methanol T=20 - 23°C; 18.5 h; Inert atmosphere;
参考文献
Jiang, Xinglong; Lee, George T.; Prasad, Kapa; Repic, Oljan
Organic Process Research and Development, 2008 , vol. 12, # 6 p. 1137 - 1141
反应条件
potassium carbonate in ethyl acetate; acetone T=25 - 90°C; 175.2 h;
参考文献
Cheung, Adrian Wai-Hing; Guertin, Kevin Richard; Haynes, Nancy-Ellen; Mertz, Eric; Qi, Lida; Qian, Yimin; Scott, Nathan Robert
Patent: US2012/258982 A1, 2012 ;
Location in patent: Page/Page column 53 ;
US 20120258982 A1
参考文献
Ferring B.V.
Patent: EP1512687 A1, 2005 ;
Location in patent: Page/Page column 11 ;
参考文献
WO2009/36996 A2, ;
Page/Page column 83 ;
WO 2009/036996 A2
反应条件
XeF2 in dichloromethane 3 h; Ambient temperature;
参考文献
Nongkunsarn, Pakawan; Ramsden, Christopher A.
Journal of the Chemical Society - Perkin Transactions 1, 1996 , # 2 p. 121 - 122
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane 5 h; Heating / reflux;
参考文献
US2006/14945 A1, ;
Page/Page column 60 ;
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane T=80°C;
参考文献
WO2009/36996 A2, ;
Page/Page column 83-84 ;
WO 2009/036996 A2
反应条件
N-bromosuccinmide; azobisisobutyronitrile in tetrachloromethane
反应条件
1: With N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in tetrachloromethane T=100°C; 20 h; 2: With silver nitrate in water; acetone 24 h; Darkness;
参考文献
US2012/258982 A1, ;
Page/Page column 53 ;
US 20120258982 A1
反应条件
N-bromosuccinmide; dibenzoyl peroxide 5 h; Reflux;
参考文献
WO2011/100433 A1, ;
Page/Page column 56 ;
WO 2011/100433 A1
