2-二乙氨基氯乙烷盐酸盐合成路线 （共 91 条）
参考文献
Acta Chemica Scandinavica (1947-1973), , vol. 13, p. 1585,1599
反应条件
(i) Cu, H2O, (ii) K2CO3; Multistep reaction;
参考文献
Thuillier,G. et al.
Bulletin de la Societe Chimique de France, 1963 , p. 1087 - 1090
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Gelbard,G.; Rumpf,P.
Bulletin de la Societe Chimique de France, 1969 , p. 1161 - 1170
参考文献
Fulton et al.
Pr.roy.Soc.<B>, 1950 , vol. 137, p. 339,358
反应条件
sodium hydride in N,N-dimethyl-formamide T=80°C; 72 h;
参考文献
Jones, Charles D.; Jevnikar, Mary G.; Pike, Andrew J.; Peters, Mary K.; Black, Larry J.; at al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1057 - 1066
反应条件
potassium hydroxide in chlorobenzene
参考文献
Sill; Andrews; Sweet; Hoffman; Tiernan; Grisar; Fleming; Mayer
Journal of Medicinal Chemistry, 1974 , vol. 17, # 9 p. 965 - 968
反应条件
1: 4-hydroxy-benzaldehyde With potassium carbonate in acetone 2 h; Inert atmosphereReflux; 2: 2-diethylamino-1-chloroethane hydrochloride With potassium iodide in acetone Inert atmosphereReflux;
参考文献
Yadav, Yogesh; MacLean, Erin D.; Bhattacharyya, Annyt; Parmar, Virinder S.; Balzarini, Jan; Barden, Christopher J.; Too, Catherine K.L.; Jha, Amitabh
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 9 p. 3858 - 3866
反应条件
potassium hydroxide in ethanol 16 h; Heating / reflux;
参考文献
Honold, Konrad; Kaluza, Klaus; Masjost, Birgit; Schaefer, Wolfgang; Scheiblich, Stefan
Patent: US2008/9492 A1, 2008 ;
Location in patent: Page/Page column 17 ;
反应条件
1: 61 percent / NaOEt / ethanol / 16 h / Heating 2: 1.) tris(dibenzylideneacetone)dipalladium, Ph3As, CuI, LiCl, 2.) CuCl2 / 1.) N-methylpyrrolidone, 45 deg C, 96 h, 2.) THF, 18 h View Scheme
参考文献
Cummins
Synthetic Communications, 1995 , vol. 25, # 24 p. 4071 - 4079
参考文献
Hager; Al-Jaleel
Journal of the American Pharmaceutical Association (1912-1977), 1955 , vol. 44, p. 654
反应条件
N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide in dichloromethane; water T=25 - 35°C; 18 h;
参考文献
Prat, Denis; Benedetti, Francoise; Girard, Gilles Franc; Bouda, Lahlou Nait; Larkin, John; Wehrey, Christian; Lenay, Jacques
Organic Process Research and Development, 2004 , vol. 8, # 2 p. 219 - 228
