（2-溴乙氧基）-特丁基二甲基硅烷合成路线 （共 17 条）
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in dichloromethane T=20°C; 15 h;
参考文献
EXELIXIS, INC.
Patent: WO2005/9389 A2, 2005 ;
Location in patent: Page/Page column 134 ;
WO 2005/009389 A2
反应条件
in N,N-dimethyl-formamide; benzene
参考文献
Eisai Co., Ltd.
Patent: US5221671 A1, 1993 ;
US 5221671 A
反应条件
carbon tetrabromide; triphenylphosphine in tetrahydrofuran T=0°C;
参考文献
WO2012/31028 A2, ;
Page/Page column 40-41 ;
反应条件
pyridine; N,N'-dimethyl-N,N'-propyleneurea; 4,4'-dimethoxy-2,2'-bipyridine; NiI2*3.5H2O; sodium iodide; zinc T=20 - 60°C; 16 h; chemoselective reaction;
参考文献
Everson, Daniel A.; Jones, Brittany A.; Weix, Daniel J.
Journal of the American Chemical Society, 2012 , vol. 134, # 14 p. 6146 - 6159
反应条件
potassium hydrogensulfate in methanol T=20°C; 1.5 h;
参考文献
Arumugam, Pandurangan; Karthikeyan, Ganesan; Perumal, Paramasivan T.
Chemistry Letters, 2004 , vol. 33, # 9 p. 1146 - 1147
反应条件
1: 1.) NaH 2: 40 percent / LAH / diethyl ether 3: 61 percent / NEt3 / CH2Cl2 4: 77 percent / N-methylmorpholine N-oxide, tetrapropylammonium per-ruthenate / CH2Cl2 View Scheme
参考文献
Nave, Jean-Francois; Casara, Patrick J.; Taylor, Debra L.; Tyms, A. Stanley; Kenny, Michael; Halazy, Serge
Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 2 p. 179 - 184
反应条件
sodium iodide in N-methyl-acetamide; acetone
参考文献
Aventis Pharmaceuticals Inc.
Patent: US6194406 B1, 2001 ;
US 6194406 B1
反应条件
tetrabutyl ammonium fluoride; potassium carbonate in tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide
参考文献
Eisai Co., Ltd.
Patent: US5221671 A1, 1993 ;
US 5221671 A
反应条件
pyridine; N,N'-dimethyl-N,N'-propyleneurea; 4,4'-dimethoxy-2,2'-bipyridine; NiI2*3.5H2O; sodium iodide; zinc T=20 - 60°C; 16 h; chemoselective reaction;
参考文献
Everson, Daniel A.; Jones, Brittany A.; Weix, Daniel J.
Journal of the American Chemical Society, 2012 , vol. 134, # 14 p. 6146 - 6159
