咪唑并[1,2-a]吡啶-7-羧酸甲酯合成路线 （共 6 条）
反应条件
1: 2-bromoacetaldehyde diethyl acetal With hydrogenchloride in water T=80°C; 4 h; 2: With sodium hydrogencarbonate in water T=20°C; 3: 2-Amino-isonicotinic acid methyl ester in water T=20°C;
参考文献
ALMIRALL, S.A.; GRIMA POVEDA, Pedro Manuel; AGUILAR IZQUIERDO, Nuria; MIR CEPEDA, Marta; LOPEZ MARTINEZ, Manuel
Patent: WO2010/43377 A1, 2010 ;
Location in patent: Page/Page column 53-54 ;
WO 2010/043377 A1
反应条件
1: bromoacetaldehyde dimethylacetal With hydrogenchloride; water T=80°C; 1 h; 2: 2-Amino-isonicotinic acid methyl ester With sodium hydrogencarbonate in water T=90°C; 2 h;
参考文献
Forest Laboratories Holdings Limited
Patent: US2008/58350 A1, 2008 ;
Location in patent: Page/Page column 10 ;
US 20080058350 A1
反应条件
sodium hydrogencarbonate in ethanol T=80°C; 2 h;
参考文献
WO2008/45484 A1, ;
Page/Page column 66 ;
WO 2008/045484 A1
反应条件
hydrazine hydrate in methanol Reflux;
参考文献
US2012/41000 A1, ;
Page/Page column 43 ;
反应条件
hydrogenchloride; water T=50°C; 64 h;
参考文献
ALMIRALL, S.A.; GRIMA POVEDA, Pedro Manuel; AGUILAR IZQUIERDO, Nuria; MIR CEPEDA, Marta; LOPEZ MARTINEZ, Manuel
Patent: WO2010/43377 A1, 2010 ;
Location in patent: Page/Page column 54 ;
WO 2010/043377 A1
反应条件
diisobutylaluminium hydride in dichloromethane T=-60°C;
参考文献
Yamanaka; Miyake; Suda; Ohhara; Ogawa
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 6 p. 1556 - 1567
