4-(2-乙氧基-2-氧代乙基)-1,4-哌啶二羧酸1-(1,1-二甲基乙基)4-乙酯合成路线 （共 4 条）
反应条件
1: ethyl 1-tert-butyloxycarbonyl-4-piperidinecarboxylate With n-butyllithium; diisopropylamine in tetrahydrofuran T=-78°C; 1.5 h; 2: ethyl bromoacetate in tetrahydrofuran T=-78 - 20°C; 3: With water in water
参考文献
JANSSEN PHARMACEUTICA N.V.
Patent: WO2005/97794 A1, 2005 ;
Location in patent: Page/Page column 38-39 ;
WO 2005/097794 A1
反应条件
1: With sodium tetrahydroborate in ethanol T=0 - 20°C; Heating / reflux; 2: With hydrogenchloride in ethanol; water pH=5 - 6;
参考文献
ASTRAZENECA AB
Patent: WO2007/30061 A1, 2007 ;
Location in patent: Page/Page column 86; 87 ;
WO 2007/030061 A1
参考文献
JANSSEN PHARMACEUTICA N.V.
Patent: WO2005/97794 A1, 2005 ;
Location in patent: Page/Page column 39 ;
WO 2005/097794 A1
反应条件
1: ethyl 1-tert-butyloxycarbonyl-4-piperidinecarboxylate With n-butyllithium; diisopropylamine in tetrahydrofuran
T=-78°C; 1.5 h;
2: ethyl bromoacetate in tetrahydrofuran
T=-78 - 20°C;
3: With water in water
参考文献
JANSSEN PHARMACEUTICA N.V.
Patent: WO2005/97794 A1, 2005 ;
Location in patent: Page/Page column 38-39 ;
WO 2005/097794 A1
