2,4-二氯-5-氟苯甲酸合成路线 （共 11 条）
反应条件
sodium hypochlorite in 1,4-dioxane
参考文献
Hong, Jian; Zhang, Zonghua; Lei, Huoxing; Cheng, Haiying; Hu, Yufang; Yang, Wanliang; Liang, Yinglin; Das, Debasis; Chen, Shu-Hui; Li, Ge
Tetrahedron Letters, 2009 , vol. 50, # 21 p. 2525 - 2528
参考文献
Uchikawa, Osamu; Mitsui, Keita; Asakawa, Akiko; Morimoto, Shigeru; Yamamoto, Masataka; Kimura, Hiroyuki; Moriya, Takeo; Mizuno, Masahiro
Patent: US2003/187014 A1, 2003 ;
反应条件
1.1: 86 percent / conc. sulfuric acid; fuming nitric acid / 20 - 70 °C 2.1: 91 percent / thionylchloride / 1 h / Heating 3.1: Mg; ethanol; tetrachloromethane / toluene / 2 h / 70 °C 3.2: toluene / 0 - 20 °C 3.3: aq. sulfuric acid / 0 °C View Scheme
参考文献
Engler, Michael; Ruesing, Guido; Soergel, Fritz; Holzgrabe, Ulrike
Antimicrobial Agents and Chemotherapy, 1998 , vol. 42, # 5 p. 1151 - 1159
反应条件
1: 86 percent / conc. sulfuric acid; fuming nitric acid / 20 - 70 °C 2: 91 percent / thionylchloride / 1 h / Heating View Scheme
参考文献
Engler, Michael; Ruesing, Guido; Soergel, Fritz; Holzgrabe, Ulrike
Antimicrobial Agents and Chemotherapy, 1998 , vol. 42, # 5 p. 1151 - 1159
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US6348474 B1, 2002 ;
Location in patent: Page column 128 ;
反应条件
thionyl chloride 2 h; Heating;
参考文献
Journal of Fluorine Chemistry, , vol. 106, # 2 p. 173 - 179
Journal of Fluorine Chemistry, , vol. 123, # 2 p. 163 - 169
反应条件
1: SOCl2 / 2 h / Heating 2: 10 h / 40 °C View Scheme
参考文献
Shi, Wei; Qian, Xuhong; Song, Gonghua; Zhang, Rong; Li, Rongpo
Journal of Fluorine Chemistry, 2000 , vol. 106, # 2 p. 173 - 179
参考文献
Karthikeyan, Mari Sithambaram; Prasad, Dasappa Jagadeesh; Mahalinga, Manjathuru; Holla, Bantwal Shivarama; Kumari, Nalilu Suchetha
European Journal of Medicinal Chemistry, 2008 , vol. 43, # 1 p. 25 - 31
反应条件
nitric acid in methanol; ice-water
反应条件
sulfuric acid; nitric acid
参考文献
Tetrahedron Letters, , vol. 50, # 21 p. 2525 - 2528
