2-[2-(2-叠氮基乙氧基)乙氧基]乙醇合成路线 （共 21 条）
反应条件
water; triphenylphosphine in tetrahydrofuran 4 h; Ambient temperature;
参考文献
Dykhuizen, Emily C.; Kiessling, Laura L.
Organic Letters, 2009 , vol. 11, # 1 p. 193 - 196
反应条件
1: palladium on carbon; hydrogen / tetrahydrofuran 2: dichloromethane 3: sodium hydroxide / tetrahydrofuran; toluene / 45 °C 4: hydrogenchloride; water / 1 h 5: potassium carbonate / water / 16.75 h / 20 °C View Scheme
参考文献
Schmidt, Florian; Rosnizeck, Ina C.; Spoerner, Michael; Kalbitzer, Hans Robert; Koenig, Burkhard
Inorganica Chimica Acta, 2011 , vol. 365, # 1 p. 38 - 48
反应条件
potassium hydroxide in N,N-dimethyl-formamide T=45°C; 24 h;
参考文献
Sang Won Jeong; O'Brien
Journal of Organic Chemistry, 2001 , vol. 66, # 14 p. 4799 - 4802
反应条件
1: 8-azido-3,6-dioxa-1-octanol With sodium hydride in N,N-dimethyl-formamide T=0°C; 0.5 h; 2: 2-iodoacetic acid sodium salt in N,N-dimethyl-formamide T=20°C; 32 h;
参考文献
Schneekloth, Ashley R.; Pucheault, Mathieu; Tae, Hyun Seop; Crews, Craig M.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 22 p. 5904 - 5908
反应条件
1: 80 percent / BF3*Et2O / CH2Cl2 / 6 h / Ambient temperature 2: aq. KOH / ethanol / 6 h / Heating View Scheme
参考文献
Devigny, Christian; Perez-Balderas, Francisco; Hoogeland, Bastiaan; Cuboni, Serena; Wachtel, Rudolf; Mauch, Christoph P.; Webb, Katharine J.; Deussing, Jan M.; Hausch, Felix
Journal of the American Chemical Society, 2011 , vol. 133, # 23 p. 8927 - 8933
反应条件
in tetrahydrofuran; dichloromethane; water
参考文献
Novo Nordisk A/S
Patent: US2009/36353 A1, 2009 ;
反应条件
1: 76 percent / KOH / dimethylformamide / 24 h / 45 °C 2: 89 percent / 1,3-propanedithiol / methanol / 48 h / 20 °C View Scheme
参考文献
Sang Won Jeong; O'Brien
Journal of Organic Chemistry, 2001 , vol. 66, # 14 p. 4799 - 4802
反应条件
1: 100 percent / triphenylphosphine, H2O / tetrahydrofuran / 4 h / Ambient temperature 2: 93 percent / KOH / H2O; dioxane / 1) 0 deg C, 1 h, 2) room temp., 4 h View Scheme
参考文献
Moreau, Julie; Marchand-Brynaert, Jacqueline
European Journal of Organic Chemistry, 2011 , # 9 p. 1641 - 1644
反应条件
5-palladium/activated carbon; hydrogen in methanol
参考文献
Shimokawa, Kenichiro; Yamada, Kaoru; Ohno, Osamu; Oba, Yuichi; Uemura, Daisuke
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 1 p. 92 - 95
反应条件
1: palladium 10 on activated carbon; hydrogen / ethanol 2: ethanol 3: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 4 h 4: sodium hydroxide / water; toluene / 100 °C 5: triethylamine / dichloromethane 6: sodium azide / N,N-dimethyl-formamide / 70 °C 7: palladium 10 on activated carbon; hydrogen / ethanol View Scheme
参考文献
Gerard, Estelle; Meulle, Aline; Feron, Olivier; Marchand-Brynaert, Jacqueline
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 1 p. 586 - 590
