N-((4-氟苯基)甲基)乙酰胺合成路线 （共 6 条）
反应条件
N-Benzyldiacetamide; potassium hydride in diethylene glycol dimethyl ether T=120°C; 18 h;
参考文献
Bell, Christen M.; Kissounko, Denis A.; Gellman, Samuel H.; Stahl, Shannon S.
Angewandte Chemie - International Edition, 2007 , vol. 46, # 5 p. 761 - 763
反应条件
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine in DMF (N,N-dimethyl-formamide)
T=0 - 20°C; 2 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2004/294 A1, 2003 ;
Location in patent: Page 41 ;
WO 2004/000294 A1
反应条件
1: With trimethylsilyl trifluoromethanesulfonate
T=20°C; Pinner Imino Ether Synthesis; 65 h;
2: With water
参考文献
Pfaff, Dominik; Nemecek, Gregor; Podlech, Joachim
Beilstein Journal of Organic Chemistry, 2013 , vol. 9, p. 1572 - 1577
反应条件
N-Benzyldiacetamide; potassium hydride in diethylene glycol dimethyl ether
T=120°C; 18 h;
参考文献
Bell, Christen M.; Kissounko, Denis A.; Gellman, Samuel H.; Stahl, Shannon S.
Angewandte Chemie - International Edition, 2007 , vol. 46, # 5 p. 761 - 763
参考文献
Shine, Henry J.; Yueh, Wang
Journal of Organic Chemistry, 1994 , vol. 59, # 13 p. 3553 - 3559
参考文献
Rozhkov,I.N.; Alyev,I.Y.
Tetrahedron, 1975 , vol. 31, p. 977 - 981
