2-氨基-3-[4-(苄氧基)苯基]-1-丙醇合成路线 （共 14 条）
反应条件
1: (S)-β-amino-4-(phenylmethoxy)benzenepropanol With sodium hydride in tetrahydrofuran T=20°C; 0.5 h; 2: chloroacetic acid ethyl ester in tetrahydrofuran 3 h; Heating; Further stages.;
参考文献
Richter, Jeremy M.; Whitefield, Brandon W.; Maimone, Thomas J.; Lin, David W.; Castroviejo, M. Pilar; Baran, Phil S.
Journal of the American Chemical Society, 2007 , vol. 129, # 42 p. 12857 - 12869
反应条件
toluene-4-sulfonic acid in tetrahydrofuran; dichloromethane
pH=13; 6 h; Heating;
参考文献
Richter, Jeremy M.; Whitefield, Brandon W.; Maimone, Thomas J.; Lin, David W.; Castroviejo, M. Pilar; Baran, Phil S.
Journal of the American Chemical Society, 2007 , vol. 129, # 42 p. 12857 - 12869
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
T=20°C; 6 h;
参考文献
Nguyen, Quynh Pham Bao; Kim, Jae Nyoung; Kim, Taek Hyeon
Tetrahedron Letters, 2009 , vol. 50, # 28 p. 4015 - 4018
反应条件
4-methyl-morpholine; hydrogenchloride; sodium tetrahydroborate in tetrahydrofuran; methanol
参考文献
Abbott Laboratories
Patent: US6274715 B1, 2001 ;
反应条件
1: N-methylmorpholine / tetrahydrofuran / -15 °C
2: NaBH4 / methanol; tetrahydrofuran / 1.5 h
3: Me3SiCl; PhOH / CH2Cl2 / 1 h / 20 °C
View Scheme
参考文献
Caplar, Vesna; Raza, Zlata; Katalenic, Darinka; Zinic, Mladen
Croatica Chemica Acta, 2003 , vol. 76, # 1 p. 23 - 36
反应条件
1: thionyl chloride / 20 h / Heating
2: triethylamine / methanol / 17 h / 20 °C
3: 100 percent / potassium carbonate; potassium iodide / acetone / 4 h / Heating
4: 87 percent / sodium borohydride; lithium iodide / tetrahydrofuran / 3 h / Heating
5: 68 percent / p-toluenesulfonic scid / CH2Cl2; tetrahydrofuran / 20 h / 20 °C
View Scheme
参考文献
Oila, Markku J.; Tois, Jan E.; Koskinen, Ari M.P.
Tetrahedron, 2005 , vol. 61, # 45 p. 10748 - 10756
反应条件
1: triethylamine / methanol / 17 h / 20 °C
2: 100 percent / potassium carbonate; potassium iodide / acetone / 4 h / Heating
3: 87 percent / sodium borohydride; lithium iodide / tetrahydrofuran / 3 h / Heating
4: 68 percent / p-toluenesulfonic scid / CH2Cl2; tetrahydrofuran / 20 h / 20 °C
View Scheme
参考文献
Oila, Markku J.; Tois, Jan E.; Koskinen, Ari M.P.
Tetrahedron, 2005 , vol. 61, # 45 p. 10748 - 10756
反应条件
1: 87 percent / sodium borohydride; lithium iodide / tetrahydrofuran / 3 h / Heating
2: 68 percent / p-toluenesulfonic scid / CH2Cl2; tetrahydrofuran / 20 h / 20 °C
View Scheme
参考文献
Oila, Markku J.; Tois, Jan E.; Koskinen, Ari M.P.
Tetrahedron, 2005 , vol. 61, # 45 p. 10748 - 10756
反应条件
1: 100 percent / potassium carbonate; potassium iodide / acetone / 4 h / Heating
2: 87 percent / sodium borohydride; lithium iodide / tetrahydrofuran / 3 h / Heating
3: 68 percent / p-toluenesulfonic scid / CH2Cl2; tetrahydrofuran / 20 h / 20 °C
View Scheme
参考文献
Oila, Markku J.; Tois, Jan E.; Koskinen, Ari M.P.
Tetrahedron, 2005 , vol. 61, # 45 p. 10748 - 10756
反应条件
1: 18-crown-6 ether; potassium carbonate / N,N-dimethyl-formamide / 24 h / 40 °C
2: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
3: acetyl chloride / methanol; ethyl acetate / 24.5 h / 0 - 20 °C
View Scheme
参考文献
He, Xiping; Li, Jia; Lu, Cuifen; Chen, Zuxin; Yang, Guichun
Canadian Journal of Chemistry, 2011 , vol. 89, # 1 p. 88 - 91
