1: 5-amino-4-imidazolecarboxamide With hydrogenchloride; sodium nitrite in water T=0°C; 2: 1-chloro-2-isocyanato-ethane in water; ethyl acetate T=30°C; 48 h;
hydrogenchloride; sodium nitrite in water 1.) 0 deg C, 15 min, 2.) 0 deg C to 20 deg C, 1 h;
参考文献
Wang, Yongfeng; Wheelhouse, Richard T.; Zhao, Linxiang; Langnel, David A. F.; Stevens, Malcolm F. G.
Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 10 p. 1669 - 1675
Lowe, Philip R.; Schwalbe, Carl H.; Stevens, Malcolm F.G.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1985 , p. 357 - 362
1: 77 percent / concd. sulfuric acid, sodium nitrite / H2O / 2.5 h / 35 °C 2: 99 percent / thionyl chloride, N,N-dimethylformamide / 2.5 h / Heating 3: 67 percent / 2.5 h / Ambient temperature View Scheme
参考文献
Horspool, K. R.; Stevens, M. F. G.; Newton, C. G.; Lunt, E.; Walsh, R. J. A.; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 5 p. 1393 - 1399
