乙基5-甲氧基-2-甲基-苯甲酸酯合成路线 （共 3 条）
反应条件
1: 1) NBS / 1) CCl4, 2) DMSO 2: 1) LDA, 2) LDA / 1) THF, -70 deg C, 10 min., 2) THF, -40 deg C, 10 min 3: 90 percent / 10percent aq. NaOH, 30percent aq. H2O2 / ethanol / a) 5 h, 75 deg C, b) 12 h, room temp. View Scheme
参考文献
Bhawal, Baburao M.; Khanapure, Subhash P.; Zhang, Hongming; Biehl, Edward R.
Journal of Organic Chemistry, 1991 , vol. 56, # 8 p. 2846 - 2849
反应条件
1: ethyl 3-hydroxy-6-methylbenzoate With sodium hydride in N,N-dimethyl-formamide
T=20°C; 3.16667 h;
2: methyl iodide in N,N-dimethyl-formamide
T=20°C;
参考文献
The United States of America, as represented by the Secretary, Department of Health and Human Services; Science Applications International Corporation (SAIC); Albany Molecular Research, Inc.
Patent: WO2009/42907 A1, 2009 ;
Location in patent: Page/Page column 35 ;
WO 2009/042907 A1
参考文献
Stork et al.
Journal of the American Chemical Society, 1953 , vol. 75, p. 3197,3202
