DL-α-Phosphatidylcholine合成路线 （共 5 条）
反应条件
tetrafluoroboric acid in dichloromethane
T=20°C; Methylation; 3 h;
参考文献
Noskov; Shishkov; Kruglyak; Kiselevskii; Dobryanskii; Maksimtseva; Sokal'skii
Pharmaceutical Chemistry Journal, 1996 , vol. 30, # 10 p. 607 - 610
反应条件
in ethanol; chloroform; acetonitrile
30 h; Ambient temperature;
参考文献
Kertscher; Ostermann
Pharmazie, 1987 , vol. 42, # 11 p. 713 - 715
反应条件
1: 73.4 percent / phosphocholine sodium salt / methanol / 20 h / Heating
2: 50.5 percent / fluoboric acid / CH2Cl2 / 3 h / 20 °C
View Scheme
参考文献
Noskov; Shishkov; Kruglyak; Kiselevskii; Dobryanskii; Maksimtseva; Sokal'skii
Pharmaceutical Chemistry Journal, 1996 , vol. 30, # 10 p. 607 - 610
反应条件
1: 73.4 percent / phosphocholine sodium salt / methanol / 20 h / Heating
2: 50.5 percent / fluoboric acid / CH2Cl2 / 3 h / 20 °C
View Scheme
参考文献
Noskov; Shishkov; Kruglyak; Kiselevskii; Dobryanskii; Maksimtseva; Sokal'skii
Pharmaceutical Chemistry Journal, 1996 , vol. 30, # 10 p. 607 - 610
反应条件
1: KOH / tetrahydrofuran; dimethylsulfoxide / 2 h / Ambient temperature
2: pyridine / benzene / 2 h / O deg C to room temp.
3: H2O / 1.5 h / Heating
4: 2.) Ag2CO3 / 1.) toluene, 3 d, room temp., 2.) methanol, 1.5 h reflux
View Scheme
参考文献
Tsushima; Yoshioka; Tanida; Nomura; Nojima; Hozumi
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 9 p. 3260 - 3270
