1-甲氧基甲氧基-2-(三氟甲氧基)苯合成路线 （共 3 条）
反应条件
1.1: n-butyllithium / cyclohexane; tetrahydrofuran / 1.25 h / -60 °C / Inert atmosphere 1.2: 0.5 h / 20 °C 2.1: hydrogenchloride; water / cyclohexane; tetrahydrofuran / 15 h / 60 °C View Scheme
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane
T=5 - 20°C;
参考文献
ABBOTT LABORATORIES; GOMTSYAN, Arthur R.; VOIGHT, Eric A.; BAYBURT, Erol K.; CHEN, Jun; DAANEN, Jerome F.; DIDOMENICO, Stanley, Jr.; KORT, Michael E.; KYM, Philip R.; MCDONALD, Heath A.; PERNER, Richard J.; SCHMIDT, Robert G.
Patent: WO2010/45402 A1, 2010 ;
Location in patent: Page/Page column 68 ;
WO 2010/045402 A1
反应条件
1.1: n-butyllithium / cyclohexane; tetrahydrofuran / 1.25 h / -60 °C / Inert atmosphere
1.2: 0.5 h / 20 °C
2.1: hydrogenchloride; water / cyclohexane; tetrahydrofuran / 15 h / 60 °C
3.1: N-bromosuccinmide / dichloromethane / 0.5 h / 20 °C
View Scheme
参考文献
Kobashi, Seiichi; Uda, Junichiro; Miyata, Sachiho; Inoue, Tsutomu; Ashizawa, Naoki; Matsumoto, Koji; Taniguchi, Tetsuya; Iwanaga, Takashi; Nagata, Osamu
Patent: US2012/184587 A1, 2012 ;
