4-溴-2-甲基-2H-吡唑-3-羧酸合成路线 （共 12 条）
反应条件
potassium permanganate in water T=60°C;
参考文献
Manaev, Yu. A.; Andreeva, M. A.; Perevalov, V. P.; Stepanov, B. I.; Dubrovskaya, V. A.; Seraya, V. I.
J. Gen. Chem. USSR (Engl. Transl.), 1982 , vol. 52, # 11 p. 2592 - 2598,2291 - 2296
反应条件
bromine in acetic acid
参考文献
Manaev, Yu. A.; Andreeva, M. A.; Perevalov, V. P.; Stepanov, B. I.; Dubrovskaya, V. A.; Seraya, V. I.
J. Gen. Chem. USSR (Engl. Transl.), 1982 , vol. 52, # 11 p. 2592 - 2598,2291 - 2296
参考文献
WO2005/66147 A1, ;
Page/Page column 183 ;
WO 2005/066147 A1
反应条件
1: 75 percent / KMnO4 / H2O 2: 44 percent / bromine / acetic acid View Scheme
参考文献
J. Gen. Chem. USSR (Engl. Transl.), , vol. 52, # 11 p. 2592 - 2598,2291 - 2296
反应条件
anschliessend mit CO2;<neben anderen Verbindungen>;
参考文献
Justus Liebigs Annalen der Chemie, , vol. 625, p. 55,60
反应条件
thionyl chloride 18 h; Reflux;
参考文献
WO2013/189862 A1, ;
Page/Page column 17 ;
反应条件
sulfuric acid; nitric acid T=65 - 70°C; 4 h;
参考文献
Manaev, Yu. A.; Andreeva, M. A.; Perevalov, V. P.; Stepanov, B. I.; Dubrovskaya, V. A.; Seraya, V. I.
J. Gen. Chem. USSR (Engl. Transl.), 1982 , vol. 52, # 11 p. 2592 - 2598,2291 - 2296
反应条件
sulfuric acid; nitric acid T=60 - 65°C; 2 h;
参考文献
Manaev, Yu. A.; Andreeva, M. A.; Perevalov, V. P.; Stepanov, B. I.; Dubrovskaya, V. A.; Seraya, V. I.
J. Gen. Chem. USSR (Engl. Transl.), 1982 , vol. 52, # 11 p. 2592 - 2598,2291 - 2296
反应条件
1: thionyl chloride / 18 h / |Reflux
2: caesium carbonate; tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 12 h / 80 °C / |Inert atmosphere
View Scheme
参考文献
F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; GABRIEL, Stephen Deems; HAMILTON, Matthew Michael; QIAN, Yimin; SIDDURI, Achyutharao
Patent: WO2013/189862 A1, 2013 ;
参考文献
Perevalov, V. P.; Andreeva, M. A.; Baryshnenkova, L. I.; Manaev, Yu. A.; Yamburg, G. S.; et al.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1983 , vol. 19, # 12 p. 1326 - 1330
Khimiya Geterotsiklicheskikh Soedinenii, 1983 , vol. 19, # 12 p. 1676 - 1679
