5'-O-(4,4'-二甲氧基三苯甲基)-2'-脱氧胸苷-3'-(甲基-N,N-二异丙基)亚磷酰胺合成路线 （共 6 条）
参考文献
Herdering, Wilhelm; Seela, Frank
Journal of Organic Chemistry, 1985 , vol. 50, # 25 p. 5314 - 5323
反应条件
1: 67 percent / PCl3 / diethyl ether / 1.) -10 grad C, 2.5 h, 2.) room temperature, 1 h
2: 1.) isopropylethylamine / 1.) CH2Cl2, -10 grad C, 30 min, 2.) CH2Cl2, 30 min
View Scheme
参考文献
Tanaka, Toshiki; Tamatsukuri, Sigeru; Ikehara, Morio
Tetrahedron Letters, 1986 , vol. 27, # 2 p. 199 - 202
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane
Ambient temperature;
参考文献
Farschtschi; Gorenstein
Tetrahedron Letters, 1988 , vol. 29, # 52 p. 6843 - 6846
反应条件
1: 95 percent / KI, Al2Cl6 / CH2Cl2 / 10 h, -65 deg C then 3 h, -35 deg C then 5 h, -20 deg C then 10 h rt
2: diisopropylethylamine / CH2Cl2 / Ambient temperature
View Scheme
参考文献
Farschtschi; Gorenstein
Tetrahedron Letters, 1988 , vol. 29, # 52 p. 6843 - 6846
反应条件
N,N-diisopropylamine tetrazolide
参考文献
Ferris; Peyser
Nucleosides and Nucleotides, 1994 , vol. 13, # 5 p. 1087 - 1111
反应条件
N-ethyl-N-isopropylamine
1.) CH2Cl2, -10 grad C, 30 min, 2.) CH2Cl2, 30 min; Yield given. Multistep reaction;
参考文献
Tanaka, Toshiki; Tamatsukuri, Sigeru; Ikehara, Morio
Tetrahedron Letters, 1986 , vol. 27, # 2 p. 199 - 202
