(R)-4-氯-3-羟基丁腈合成路线 （共 13 条）
反应条件
sodium hydroxide; Escherichia coli JM109/pST111 (FERM ABP-10922) in water T=20°C; pH=7.5 - 7.6; 23 h; Product distribution / selectivity;
参考文献
Mitsubishi Rayon Co. Ltd.
Patent: EP2096103 A1, 2009 ;
Location in patent: Page/Page column 19-20 ;
反应条件
1: T=45°C; 4 h; 2: With sulfuric acid in water regioselective reaction;
参考文献
Li, Xu Qin; Yang, Yun Xu; Wang, Wei Li; Hu, Bin; Xue, Hui Min; Zhang, Tian Yi; Zhang, Xue Tao
Chinese Chemical Letters, 2011 , vol. 22, # 7 p. 765 - 767
反应条件
1: in methanol 6 h; 2: With hydrogenchloride in methanol; water
参考文献
Yang, Yunxu; Wang, Weili; Wumaier, Aikeremu; Sheng, Ruilong; Zhang, Xuetao; Zhang, Tianyi
Journal of Chemical Research, 2011 , vol. 35, # 6 p. 371 - 372
反应条件
H-lyase B (purified from Escherichia coli bearing its gene from Corynebacterium sp.) in water T=20°C; 2 h; in Tris-H2SO4 buffer, pH 8.0; KCN concn varied; also in absence of enzyme; optical purity and yield evolution in time; Product distribution;
参考文献
Nakamura, Tetsuji; Nagasawa, Toru; Yu, Fujio; Watanabe, Ichiro; Yamada, Hideaki
Tetrahedron, 1994 , vol. 50, # 41 p. 11821 - 11826
反应条件
bacterial cells DS-K-717; calcium carbonate in phosphate buffer T=30°C; pH=6.0; 8 h; Product distributionEnzyme kinetics; Further Variations:Reagents;
参考文献
Idogaki, Hideaki; Kasai, Naoya; Takeuchi, Motoko; Hatada, Miki; Suzuki, Toshio
Tetrahedron Asymmetry, 2001 , vol. 12, # 3 p. 369 - 373
反应条件
in methanol 17 h; Ambient temperature;
参考文献
Tetrahedron: Asymmetry, , vol. 4, # 1 p. 133 - 141
反应条件
H-lyase B (purified from Escherichia coli bearing its gene from Corynebacterium sp.) in water T=20°C; in Tris-H2SO4 buffer, pH 8.0; KCN concn varied; also in absence of enzyme; optical purity and yield evolution in time; Product distribution;
参考文献
Tetrahedron, , vol. 50, # 41 p. 11821 - 11826
参考文献
Tetrahedron, , vol. 50, # 41 p. 11821 - 11826
参考文献
Inoue; Kenji; Kutsuki; Hidetoshi; Hasegawa; Junzo; Takahashi; Satomi
Patent: US4910320 A1, 1990 ;
参考文献
Inoue; Kenji; Kutsuki; Hidetoshi; Hasegawa; Junzo; Takahashi; Satomi
Patent: US4910320 A1, 1990 ;
