1-Boc-4-哌啶甲酸合成路线

84358-13-41-Boc-4-哌啶甲酸→441774-09-01-叔丁氧羰基-4-烯丙基-4-哌啶甲酸甲酯

参考文献

Xue, Chu-Biao; Chen, Xiao-Tao; He, Xiaohua; Roderick, John; Corbett, Ronald L.; Ghavimi, Bahman; Liu, Rui-Qin; Covington, Maryanne B.; Qian, Mingxin; Ribadeneira, Maria D.; Vaddi, Krishna; Trzaskos, James; Newton, Robert C.; Duan, James J.-W.; Decicco, Carl P.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 17 p. 4453 - 4459

100-39-0溴化苄+84358-13-41-Boc-4-哌啶甲酸→177990-33-91,4-哌啶二羧酸 1-(1,1-二甲基乙基) 4-(苯基甲基)酯

参考文献

TORAY INDUSTRIES, INC.
Patent: EP2009006 A1, 2008 ;
Location in patent: Page/Page column 78 ;

84358-13-41-Boc-4-哌啶甲酸+100-51-6苯甲醇→177990-33-91,4-哌啶二羧酸 1-(1,1-二甲基乙基) 4-(苯基甲基)酯

参考文献

DeCorte, Bart L.; DesJarlais, Renee L.; Huang, Yifang; Parker, Michael H.; Hlasta, Dennis J.
Patent: US2011/224209 A1, 2011 ;
Location in patent: Page/Page column 24 ;
US 20110224209 A1

84358-13-41-Boc-4-哌啶甲酸→177990-33-91,4-哌啶二羧酸 1-(1,1-二甲基乙基) 4-(苯基甲基)酯

参考文献

Merck and Co., Inc.
Patent: US5891889 A1, 1999 ;
US 5891889 A

38330-80-2丙二酸单甲酯钾盐+84358-13-41-Boc-4-哌啶甲酸→479630-08-5N-BOC-4-(2-乙氧羰基乙酰基)哌啶

参考文献

Asinex Limited; KAZULKIN, Denis Nikolaevich; KOCHUBEY, Valeriy Sergeevich
Patent: EP2719696 A1, 2014 ;
Location in patent: Paragraph 0221; 0222 ;

2033-24-1米氏酸+64-17-5乙醇+84358-13-41-Boc-4-哌啶甲酸→479630-08-5N-BOC-4-(2-乙氧羰基乙酰基)哌啶

参考文献

Bashford, Katherine E.; Burton, Matthew B.; Cameron, Stuart; Cooper, Anthony L.; Hogg, Rebecca D.; Kane, Peter D.; MacManus, David A.; Matrunola, Christopher A.; Moody, Christopher J.; Robertson, Avril A. B.; Warne, Mark R.
Tetrahedron Letters, 2003 , vol. 44, # 8 p. 1627 - 1629

84358-13-41-Boc-4-哌啶甲酸→479630-08-5N-BOC-4-(2-乙氧羰基乙酰基)哌啶

参考文献

INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION; MEROUEH, Samy O.
Patent: WO2013/25939 A2, 2013 ;

84358-13-41-Boc-4-哌啶甲酸→91419-48-61-叔丁氧羰基-4-哌啶甲酰胺

参考文献

Itani, Hiromichi; Ito, Harunobu; Sakata, Yoshihiko; Hatakeyama, Yoshifumi; Oohashi, Hiroko; Satoh, Yoshinari
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 5 p. 757 - 761

84358-13-41-Boc-4-哌啶甲酸→91419-52-2N-Boc-4-氰基哌啶

参考文献

Schlewer; Wermuth; Chambon
European Journal of Medicinal Chemistry, 1984 , vol. 19, # 2 p. 181 - 186

84358-13-41-Boc-4-哌啶甲酸+109-89-7二乙胺→1903-67-9N,N-二乙基哌啶-4-甲酰胺

参考文献

Theravance, Inc.
Patent: US2005/203133 A1, 2005 ;
Location in patent: Page/Page column 26 ;
US 20050203133 A1