1-Boc-4-哌啶甲酸合成路线 （共 100 条）
反应条件
sodium hydrogencarbonate in 1,4-dioxane Acylation;
参考文献
Kim, Yong-Chul; Zhao, Long-Xuan; Kim, Tae-Hyung; Je, Sun-Mi; Kim, Eun-Kyung; Choi, Heesung; Chae, Whi-Gun; Park, Minsoo; Choi, Jongwon; Jahng, Yurngdong; Lee, Eung-Seok
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 7 p. 609 - 613
反应条件
sodium hydroxide; anhydrous potassium hydrogen sulfate in water
反应条件
sodium carbonate in water
反应条件
in 1,4-dioxane; water
参考文献
ELI LILLY AND COMPANY
Patent: EP806411 A2, 1997 ;
反应条件
ethylenediaminetetraacetic acid in phosphate buffer; dimethyl sulfoxide T=29 - 31°C; pH=8.00;
参考文献
Advanced Synthesis and Catalysis, , vol. 349, # 8-9 p. 1475 - 1480
反应条件
1: Et3N 2: aq. NaOH View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 5 p. 757 - 761
反应条件
sodium carbonate in 1,4-dioxane; water 12 h; Ambient temperature;
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 38, # 1 p. 53 - 60
反应条件
1: hydrazine hydrate / methanol / |Reflux 2: |Reflux 3: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C View Scheme
反应条件
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 18 h / 20 °C 2: hydrogenchloride / ethyl acetate; water / 2 h / 20 °C View Scheme
参考文献
Hu, Suwen; Gu, Quan; Wang, Zhilong; Weng, Zhiyong; Cai, Yunrui; Dong, Xiaowu; Hu, Yongzhou; Liu, Tao; Xie, Xin
European Journal of Medicinal Chemistry, 2014 , vol. 71, p. 259 - 266
反应条件
1.1: ClCOO-i-Bu; N-methylmorpholine 1.2: aq. NH3 2.1: 4 N aq. HCl / ethyl acetate View Scheme
参考文献
Itani, Hiromichi; Ito, Harunobu; Sakata, Yoshihiko; Hatakeyama, Yoshifumi; Oohashi, Hiroko; Satoh, Yoshinari
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 5 p. 757 - 761
