2H-吡喃-4(3H)-酮合成路线 （共 14 条）
反应条件
1: 2,3-Dihydro-4H-pyran-4-one With n-butyllithium; diisopropylamine in tetrahydrofuran T=-78 - -72°C; 1.25 h; Inert atmosphere; 2: N,N-bis(trifluoromethanesulfonyl)aniline in tetrahydrofuran T=-60 - 20°C; Inert atmosphere;
参考文献
PFIZER INC.; BENBOW, John William; LOU, Jihong; PFEFFERKORN, Jeffrey Allen; TU, Meihua Mike
Patent: WO2010/29461 A1, 2010 ;
Location in patent: Page/Page column 40 ;
WO 2010/029461 A1
反应条件
toluene-4-sulfonic acid in methanol T=80°C; 0.5 h;
参考文献
NOVARTIS AG; PFISTER, Keith B; SENDZIK, Martin
Patent: WO2011/26917 A1, 2011 ;
Location in patent: Page/Page column 66 ;
WO 2011/026917 A1
反应条件
1: toluene-4-sulfonic acid / methanol / 0.5 h / 80 °C 2: tin(IV) chloride / dichloromethane / -70 - 20 °C View Scheme
参考文献
NOVARTIS AG; PFISTER, Keith B; SENDZIK, Martin
Patent: WO2011/26917 A1, 2011 ;
WO 2011/026917 A1
反应条件
hydrogen; 5 palladium/carbon hydrated in ethanol; toluene T=20°C; 3 h; Product distribution / selectivity;
参考文献
Ube Industries, Ltd.
Patent: EP1700853 A1, 2006 ;
Location in patent: Page/Page column 14 ;
反应条件
tert-butoxide in dimethyl sulfoxide T=20°C; Inert atmosphere;
参考文献
WO2011/26917 A1, ;
Page/Page column 65 ;
WO 2011/026917 A1
反应条件
hydrogen; 5 palladium/carbon hydrated in ethanol; toluene
T=20°C; 1 h;
参考文献
Ube Industries, Ltd.
Patent: EP1700853 A1, 2006 ;
Location in patent: Page/Page column 13 ;
反应条件
toluene-4-sulfonic acid in acetone
T=25°C; 1.5 h;
参考文献
Paquette, Leo A.; Oplinger, Jeffrey A.
Tetrahedron, 1989 , vol. 45, # 1 p. 107 - 124
反应条件
Cl2AlO-bornyl in diethyl ether
T=80°C; 0.75 h;
参考文献
Aben, Rene W.; Scheeren, Hans W.
Synthesis, 1982 , # 9 p. 779 - 781
反应条件
zinc(II) chloride in tetrahydrofuran
3 h; Heating;
参考文献
Danishefsky; Webb II
Journal of Organic Chemistry, 1984 , vol. 49, # 11 p. 1955 - 1958
反应条件
hydroxy(tosyloxy)iodobenzene in dichloromethane
T=0°C; 4 h;
参考文献
Schaumann, Ernst; Kirschning, Andreas
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 5 p. 1481 - 1483
