(S)-1-(苄氧基)-3-(三苯甲游基氧基)丙烷-2-醇合成路线 （共 8 条）
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine
参考文献
VASCULAR BIOGENICS LTD.; KOVALEVSKI-ISHAI, Eti; ZINIUK, Zeev; HALPERIN, Gideon; MENDEL, Itzhak; FEIGE, Erez; YACOV, Niva; BREITBART, Eyal
Patent: WO2010/52718 A1, 2010 ;
Location in patent: Page/Page column 117-118 ;
反应条件
hydrogen; Ru2Cl4[(+)-BINAP]2(Et3N) in dichloromethane
T=20°C; P=73580.8 Torr; 96 h;
参考文献
Cesarotti, Edoardo; Mauri, Angela; Pallavicini, Marco; Villa, Luigi
Tetrahedron Letters, 1991 , vol. 32, # 34 p. 4381 - 4384
反应条件
1: 1N aq. HCl
2: 94 percent / Et3N, DMAP
View Scheme
参考文献
Sodeoka; Arai; Adachi; Uotsu; Shibasaki
Journal of the American Chemical Society, 1998 , vol. 120, # 2 p. 457 - 458
反应条件
1: 55 percent / NaH / dimethylsulfoxide / Ambient temperature
2: 95 percent / 70percent AcOH / 0.5 h / 65 °C
3: 54 percent / pyridine
View Scheme
参考文献
Ashton; Canning; Reynolds; Tolman; Karkas; Liou; Davies; DeWitt; Perry; Field
Journal of Medicinal Chemistry, 1985 , vol. 28, # 7 p. 926 - 933
反应条件
1: pyridinium chlorochromate / CH2Cl2
2: H2 / <Ru2Cl4-((S)-bis(diphenylphosphino-1,1'-binaphthalene)2>NEt3 (Ru(S)BINAP) / CH2Cl2 / 96 h / 20 °C / 73580.8 Torr
View Scheme
参考文献
Cesarotti, Edoardo; Mauri, Angela; Pallavicini, Marco; Villa, Luigi
Tetrahedron Letters, 1991 , vol. 32, # 34 p. 4381 - 4384
反应条件
1: NaH
2: 1N aq. HCl
3: 94 percent / Et3N, DMAP
View Scheme
参考文献
Sodeoka; Arai; Adachi; Uotsu; Shibasaki
Journal of the American Chemical Society, 1998 , vol. 120, # 2 p. 457 - 458
反应条件
1: 91 percent / triethylamine / CH2Cl2 / -10 - 20 °C
2: isobutanol / 20 h / Heating
3: potassium hydroxide / acetone / 20 °C
View Scheme
参考文献
Bolchi, Cristiano; Pallavicini, Marco; Fumagalli, Laura; Moroni, Barbara; Rusconi, Chiara; Valoti, Ermanno
Tetrahedron Asymmetry, 2005 , vol. 16, # 20 p. 3380 - 3384
反应条件
1: 66 percent / KOH / dimethylsulfoxide / 8 h / 20 °C
2: PPTS / methanol / 0.17 h / Heating
View Scheme
参考文献
Ashton; Canning; Reynolds; Tolman; Karkas; Liou; Davies; DeWitt; Perry; Field
Journal of Medicinal Chemistry, 1985 , vol. 28, # 7 p. 926 - 933
