aluminium trichloride; N,N-dimethyl-aniline in dichloromethane

1.1: 81 percent / pyridine / CH2Cl2 / 0.67 h / 0 - 5 °C 2.1: 1,3-bis-(diphenylphosphino)-propane; triethylamine / Pd(OAc)2 / dimethylformamide / 0.17 h 2.2: 40 percent / trioctylsilane / dimethylformamide / 12 h / 70 °C 3.1: 72 percent / sodium borohydride / CH2Cl2; methanol / 0.67 h / 20 °C 4.1: 83 percent / triphenylphosphine; N-bromo-succinimide / tetrahydrofuran / 0 - 20 °C 5.1: 100 percent / sodium sulfite; H2O / dioxane / 1 h / 100 °C 6.1: 76 percent / subtilisin; aq. NaOH / aq. phosphate buffer / 4 h / 20 °C View Scheme

1: 83 percent / conc. H2SO4 / CH2Cl2 / 6 h / 258.6 Torr / Ambient temperature 2: 74 percent / aq. Na2CO3 / acetonitrile / 15 h View Scheme

aluminium trichloride; N,N-dimethyl-aniline in dichloromethane 4 h; Heating;

aluminium trichloride; N,N-dimethyl-aniline in dichloromethane

1: 70 percent / NaH / tetrahydrofuran / -40 - 20 °C 2: 98 percent / aq. LiOH / tetrahydrofuran / 0 °C View Scheme

sodium carbonate in 1,4-dioxane; water 20 h; 0 deg C to r.t.;

trifluoroacetic acid in dichloromethane T=0 - 20°C;

potassium carbonate in 1,4-dioxane T=0°C; 4 h;

sodium carbonate in 1,4-dioxane; water