1-(4-甲基苯基)-1H-吡咯合成路线 （共 31 条）
反应条件
T=15°C; Equilibrium constant;
参考文献
Gazzetta Chimica Italiana, , vol. 115, # 9 p. 487 - 492
反应条件
T=15°C; Equilibrium constant;
参考文献
Gazzetta Chimica Italiana, , vol. 115, # 9 p. 487 - 492
反应条件
T=250°C; 0.25 h; Product distribution;
参考文献
Carbohydrate Research, , vol. 128, p. 351 - 355
反应条件
1: POCl3 / 3 h / 110 - 120 °C 2: 1.) H2NOH*HCl/Na2CO3, 2.) Ac2O / 1.) MeOH, H2O, reflux, 3 h, 2.) reflux, 3 h 3: KOH / ethane-1,2-diol / 4 h / 167 °C 4: SOCl2 / 4 h / 25 °C 5: 16 h / 25 °C View Scheme
参考文献
Bovy; Reitz; Collins; Chamberlain; Olins; Corpus; McMahon; Palomo; Koepke; Smits; McGraw; Gaw
Journal of Medicinal Chemistry, 1993 , vol. 36, # 1 p. 101 - 110
反应条件
1: POCl3 / 3 h / 110 - 120 °C 2: 1.) H2NOH*HCl/Na2CO3, 2.) Ac2O / 1.) MeOH, H2O, reflux, 3 h, 2.) reflux, 3 h 3: KOH / ethane-1,2-diol / 4 h / 167 °C 4: SOCl2 / 4 h / 25 °C 5: 16 h / 25 °C 6: 2.5 g / N-bromosuccinimide, 2,2'-azobisisobutyronitrile / CCl4 / 19 h / Heating View Scheme
参考文献
Bovy; Reitz; Collins; Chamberlain; Olins; Corpus; McMahon; Palomo; Koepke; Smits; McGraw; Gaw
Journal of Medicinal Chemistry, 1993 , vol. 36, # 1 p. 101 - 110
反应条件
trichlorophosphate T=110 - 120°C; 3 h; Yield given;
参考文献
Bovy; Reitz; Collins; Chamberlain; Olins; Corpus; McMahon; Palomo; Koepke; Smits; McGraw; Gaw
Journal of Medicinal Chemistry, 1993 , vol. 36, # 1 p. 101 - 110
反应条件
in methanol T=25°C; Electrolysis;
参考文献
Liu, Wei; Ma, Yuan; Yin, Ying-Wu; Zhao, Yu-Fen
Journal of Heterocyclic Chemistry, 2006 , vol. 43, # 3 p. 681 - 684
反应条件
1: POCl3 / 3 h / 110 - 120 °C 2: 1.) H2NOH*HCl/Na2CO3, 2.) Ac2O / 1.) MeOH, H2O, reflux, 3 h, 2.) reflux, 3 h View Scheme
参考文献
Bovy; Reitz; Collins; Chamberlain; Olins; Corpus; McMahon; Palomo; Koepke; Smits; McGraw; Gaw
Journal of Medicinal Chemistry, 1993 , vol. 36, # 1 p. 101 - 110
反应条件
hydroxylamine hydrochloride; acetic anhydride; trichlorophosphate Multistep reaction;
参考文献
Ankersen, Michael; Peschke, Bernd; Hansen, Birgit Sehested; Hansen, Thomas Kruse
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 10 p. 1293 - 1298
反应条件
1: 1-(4-Methylphenyl)pyrrole With potassium tert-butylate; lithium diisopropyl amide in tetrahydrofuran T=-75°C; 3 h; 2: carbon dioxide in tetrahydrofuran T=-75°C;
参考文献
Faigl, Ferenc; Thurner, Angelika; Vass, Bernadett; Toke, Laszlo
Journal of Chemical Research - Part S, 2003 , # 3 p. 132 - 133
