反应条件
1.1: AlCl3, aluminium chloride / 1,2-dichloro-ethane / 0.5 h / -5 - 0 °C
2.1: nitric acid / sulfuric acid / 0.5 h / 0 - 5 °C
3.1: SnCl2·2H2O / hydrogenchloride / 0.25 h / 0 - 65 °C
4.1: hydrogenchloride; sodium nitrite / water / 0.25 h / 0 - 5 °C
4.2: 0.5 h / 60 - 65 °C
5.1: sodium hydroxide; potassium permanganate / 1,4-dioxane; water / 2 h / 80 °C
View Scheme
参考文献
BIOPROJET; SUN PHARMA ADVANCED RESEARCH COMPANY LTD; CAPET, Marc; BERREBI-BERTRAND, Isabelle; ROBERT, Philippe; SCHWARTZ, Jean-Charles; LECOMTE, Jeanne-Marie; THENNATI, Rajamannar; PAL, Ranjan, Kumar; SAMANTA, Biswajit; PILLAI, Muthukumaran, Natarajan; DESAI, Japan, Nitinkumar; RANA, Dijixa, Chandubhai; PRAJAPATI, Kaushik, Dhanjubhai; PATHAK, Sandeep, Pankajbhai; PANCHAL, Bhavesh, M.; ARADHYE, Jayraj, D.
Patent: WO2012/140020 A1, 2012 ;
WO 2012/140020 A1