N-(2-甲酰基-3-甲氧基苯基)-2,2-二甲基丙酰胺合成路线 （共 7 条）
反应条件
1: m-methoxypivanilide With n-butyllithium in tetrahydrofuran T=0°C; 1 h; 2: N,N-dimethyl-formamide in tetrahydrofuran T=0 - 20°C; 3: With ammonium chloride in tetrahydrofuran; water
参考文献
GLAXO GROUP LIMITED
Patent: WO2004/46124 A1, 2004 ;
Location in patent: Page 41-42 ;
WO 2004/046124 A1
反应条件
sec.-butyllithium in tetrahydrofuran; hexane 1.) 0 deg C, 2 h, 2.) 0 deg C, 1 h; r.t., 12 h;
参考文献
Synthesis, , # 8 p. 1176 - 1180
反应条件
n-butyllithium; triethylamine 1.) hexane, tetrahydrofuran, 0 deg C, 2 h; 2.) dimethylformamide, 0 deg C, 1 h; room temp., 8 h; Yield given. Multistep reaction;
参考文献
Chemical & Pharmaceutical Bulletin, , vol. 30, # 4 p. 1257 - 1262
反应条件
potassium hexamethylsilazane in tetrahydrofuran; hexane; toluene 1.) 0 deg C, 10 min, 2.) r.t., 2 h; Yield given;
参考文献
Ubeda, J. Ignacio; Villacampa, Mercedes; Avendano, Carmen
Synthesis, 1998 , # 8 p. 1176 - 1180
反应条件
potassium hexamethylsilazane in tetrahydrofuran; hexane; toluene 1.) 0 deg C, 10 min, 2.) r.t., 2 h; Yield given;
参考文献
Ubeda, J. Ignacio; Villacampa, Mercedes; Avendano, Carmen
Synthesis, 1998 , # 8 p. 1176 - 1180
反应条件
1: 77 percent / benzene / 2 h / Ambient temperature 2: 89 percent / H2 / 5 percent Pd-C / ethanol / 1 h / 3040 Torr / Ambient temperature 3: 43 percent / 10 percent aq.hydrochloric acid / 1 h / 90 °C View Scheme
参考文献
Tamura, Yasumitsu; Chen, Ling Ching; Fujita, Masanobu; Kita, Yasuyuki
Chemical & Pharmaceutical Bulletin, 1982 , vol. 30, # 4 p. 1257 - 1262
反应条件
potassium hexamethylsilazane in tetrahydrofuran; hexane; toluene 2 h; Ambient temperature; Yield given;
参考文献
Synthesis, , # 8 p. 1176 - 1180
