alpha,alpha-二甲基苯乙酸合成路线 （共 89 条）
参考文献
Justus Liebigs Annalen der Chemie, , vol. 437, p. 254
参考文献
Helvetica Chimica Acta, , vol. 35, p. 780
参考文献
Zhurnal Obshchei Khimii, , vol. 15, p. 524,525
Chem.Abstr., , p. 4696
反应条件
1: With bromine; sodium carbonate in water T=25 - 30°C; pH=7; 2: With hydrogenchloride in water pH=1 - 2; Product distribution / selectivity;
参考文献
Divi's Laboratories Limited
Patent: EP2532644 A1, 2012 ;
Location in patent: Page/Page column 5 ;
反应条件
sulfuric acid; nitric acid
参考文献
Overberger; Gainer
Journal of the American Chemical Society, 1958 , vol. 80, p. 4561,4564
反应条件
oxygen; mercury(II) oxide in methanol; acetonitrile T=25°C; UV-irradiation;
参考文献
Habibi, Mohammad H.; Farhadi, Saeid
Journal of Chemical Research, 2004 , # 4 p. 296 - 297
反应条件
thionyl chloride Reflux;
参考文献
Li, Yanyang; Shi, Xiangfei; Xie, Ning; Zhao, Yanjin; Li, Shuxin
MedChemComm, 2013 , vol. 4, # 2 p. 367 - 370
反应条件
1: 99 percent / LiAlH4 / diethyl ether 2: 97 percent / Et3N; 4-pyrrolidinopyridine / 0.33 h / 20 °C 3: 63.5 percent / AlCl3 / CS2 / 1.5 h / 0 - 5 °C 4: 68 percent / p-TsOH*H2O / benzene / 24 h / Heating 5: 99 percent / NaOH; MeOH / 0.5 h / 20 °C 6: 89 percent / Jones reagent / acetone / 0 °C 7: 92 percent / diethyl ether / 0 °C 8: 89 percent / HCl; H2O / tetrahydrofuran / 15 h / 20 °C 9: 95 percent / NaBH4 / methanol; tetrahydrofuran / 0.5 h / 0 °C 10: 44 percent / K2CO3; KI / dimethylformamide; toluene / 7 h / Heating 11: 67.6 percent / NaOH; MeOH / 2 h / Heating View Scheme
参考文献
Divi's Laboratories Limited
Patent: EP2532644 A1, 2012 ;
反应条件
sulfuric acid T=70°C; 12 h;
参考文献
Yu, Zhoujie; Wang, Wei; Chen, Liqin
Journal of Labelled Compounds and Radiopharmaceuticals, 2011 , vol. 54, # 7 p. 352 - 356
反应条件
sodium hydrogencarbonate in N,N-dimethyl-formamide T=20°C; 40 h;
参考文献
Binggeli, Alfred; Christ, Andreas; Green, Luke Gideon Granville; Guba, Wolfgang; Maerki, Hans-Peter; Martin, Rainer Eugen; Mohr, Peter
Patent: US2006/276508 A1, 2006 ;
Location in patent: Page/Page column 31 ;
US 20060276508 A1
