alpha,alpha-二甲基苯乙酸合成路线 （共 89 条）
反应条件
water; potassium hydroxide in ethylene glycol T=100°C; 48 h; Inert atmosphere;
参考文献
Zalatan, David N.; Bois, J. Du
Journal of the American Chemical Society, 2009 , vol. 131, p. 7558 - 7559
反应条件
Et4Si; water; [((S)-(+)-3,5-bis(di(xylyl)phosphino)-[2.2]-paracyclophane)dipalladium] tetrachloride; toluene-4-sulfonic acid; lithium chloride in butanone T=90°C; P=22502.3 Torr; Sealed vialInert atmosphereAutoclave;
参考文献
WO2011/30110 A2, ;
Page/Page column 29-30 ;
反应条件
water; bis-triphenylphosphine-palladium(II) chloride in butanone T=115°C; P=40504.1 Torr; 5.5 h;
参考文献
Seayad; Jayasree; Chaudhari
Organic Letters, 1999 , vol. 1, # 3 p. 459 - 461
反应条件
hydrogenchloride; aluminium trichloride
参考文献
Helvetica Chimica Acta, , vol. 35, p. 780
反应条件
1: cumyl phenyl sulfide With lithium in diethyl ether T=3 - 8°C; 2 h; 2: carbon dioxide in diethyl ether
参考文献
Screttas, Constantinos G.; Heropoulos, Georgios A.; Micha-Screttas, Maria; Steele, Barry R.; Catsoulacos, Dimitrios P.
Tetrahedron Letters, 2003 , vol. 44, # 30 p. 5633 - 5635
反应条件
1: (i) NaNH2, benzene, (ii) /BRN= 635994/ 2: KOH / methanol View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 20, # 8 p. 1059 - 1064
反应条件
potassium hydroxide in ethylene glycol Heating;
参考文献
Kawai, Nobutaka; Shioiri, Takayuki
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 8 p. 2564 - 2573
反应条件
sodium hydroxide in methanol; water 4 h; Ambient temperature; Yield given;
参考文献
Synthesis, , # 4 p. 436 - 437
反应条件
sodium hydride in N,N-dimethyl-formamide T=10 - 20°C; Alkylation; 16 h;
参考文献
Pesticide Science, , vol. 55, # 8 p. 850 - 856
参考文献
Journal of the American Chemical Society, , vol. 71, p. 3929,3933
