3-氨基-4-苯基噻吩-2-甲酸甲酯合成路线 （共 11 条）
反应条件
sodium methylate in methanol
反应条件
hydrogenchloride; 18-crown-6 ether; potassium hydroxide in water; acetonitrile Thorpe reaction; 0.333333 h;
参考文献
Shah
E-Journal of Chemistry, 2011 , vol. 8, # 1 p. 368 - 372
反应条件
1: NaH / tetrahydrofuran / Heating 2: dimethylformamide / 20 °C 3: NaH / methanol / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 16 p. 2205 - 2208
反应条件
sodium hydride in methanol Heating;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 16 p. 2205 - 2208
反应条件
1: 80 percent / N-methylmorpholine / CH2Cl2 / 2 h / Ambient temperature 2: 1.) CH3ONa / 1.) CH3OH, 30 min, 10 deg C, 2.) CH3OH, reflux, 6 h View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 31, # 2 p. 305 - 312
反应条件
sodium methylate 1.) CH3OH, 30 min, 10 deg C, 2.) CH3OH, reflux, 6 h; Yield given. Multistep reaction;
参考文献
Journal of Heterocyclic Chemistry, , vol. 31, # 2 p. 305 - 312
反应条件
1: 1.) 75percent H2SO4, NaNO2, 2.) 50percent aq. H3PO2 / 1.) H2O, 0 deg C, 30 min, 2.) 0 deg C, 30 min 2: NaOH / aq. ethanol / 1 h / Heating 3: Quinoleine, bronze de cuivre / 0.5 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 19, p. 443 - 445
反应条件
sulfuric acid; hypophosphorous acid; sodium nitrite 1.) H2O, 0 deg C, 30 min, 2.) 0 deg C, 30 min; Multistep reaction;
参考文献
Kirsch, G.; Cagniat, D.; Cagniat, P.
Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 443 - 445
反应条件
1: 1.) 75percent H2SO4, NaNO2, 2.) 50percent aq. H3PO2 / 1.) H2O, 0 deg C, 30 min, 2.) 0 deg C, 30 min 2: NaOH / aq. ethanol / 1 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 19, p. 443 - 445
反应条件
1: methyl 3-amino-4-phenyl-2-thiophenecarboxylate With potassium hydroxide in ethanol; water
1 h; microwave irradiation;
2: phosgene in ethanol; water
T=0 - 20°C;
参考文献
Le Foulon, Francois-Xavier; Braud, Emmanuelle; Fabis, Frederic; Lancelot, Jean-Charles; Rault, Sylvain
Tetrahedron, 2003 , vol. 59, # 50 p. 10051 - 10057
