2-羟基-3-甲基苯甲醛合成路线 （共 54 条）
反应条件
sulfuric acid in acetic acid T=70°C; Condensation;
参考文献
Li, Zengmin; Jablonski, Chet
Chemical Communications, 1999 , # 16 p. 1531 - 1532
参考文献
Lock
Chemische Berichte, 1930 , vol. 63, p. 551,557
反应条件
in ethanol T=20°C; 0.5 h;
参考文献
Sheng, Gui-Hua; Cheng, Xiao-Shan; Wang, Xue; Huang, Di; You, Zhong-Lu; Zhu, Hai-Liang
Synthesis and Reactivity in Inorganic, Metal-Organic and Nano-Metal Chemistry, 2014 , vol. 44, # 6 p. 864 - 867
反应条件
bromine in dichloromethane T=0°C; 1 h;
参考文献
Baleizao, Carlos; Gigante, Barbara; Garcia, Hermenegildo; Corma, Avelino
Journal of Catalysis, 2004 , vol. 221, # 1 p. 77 - 84
反应条件
1: 98 percent / diethyl ether / 2 h / Ambient temperature 2: 90 percent / Amberlyst 15 / toluene / 24 h / 80 °C View Scheme
参考文献
Arduini, Arturo; Pochini, Andrea; Ungaro, Rocco
Synthesis, 1984 , # 11 p. 950 - 953
反应条件
1: Methyltriphenylphosphonium bromide With n-butyllithium in tetrahydrofuran T=0°C; 0.25 h; Inert atmosphere; 2: 2-Hydroxy-3-methyl-benzaldehyde in tetrahydrofuran T=0 - 20°C; Inert atmosphere;
参考文献
Murphy, Stephen K.; Bruch, Achim; Dong, Vy M.
Angewandte Chemie - International Edition, 2014 , vol. 53, # 9 p. 2455 - 2459
Angew. Chem., 2014 , vol. 126, # 09 p. 2487 - 2491,5
反应条件
1: triphenyl-methyl-phosphonium iodide With n-butyllithium in tetrahydrofuran; hexane T=0°C; 2 h; 2: 2-Hydroxy-3-methyl-benzaldehyde in tetrahydrofuran; hexane T=-78°C; Wittig reaction;
参考文献
Polito, Laura; Cravini, Massimiliano; Poletti, Laura; Lay, Luigi
Synthetic Communications, 2006 , vol. 36, # 15 p. 2203 - 2209
反应条件
1: 2-Hydroxy-3-methyl-benzaldehyde With sodium hydrogensulfite in ethanol
T=20°C;
2: 1,2-diamino-benzene in ethanol; N,N-dimethyl-formamide
2 h; Reflux;
参考文献
Tavman, Aydin; Ikiz, Serkan; Bagcigil, A. Funda; Oezguer, N. Yakut; Ak, Seyyal
Russian Journal of Inorganic Chemistry, 2010 , vol. 55, # 2 p. 215 - 222
反应条件
potassium carbonate in DMF (N,N-dimethyl-formamide)
T=50°C; 1 h;
参考文献
AVENTIS PHARMACEUTICALS INC.
Patent: WO2005/111025 A1, 2005 ;
Location in patent: Page/Page column 89-90 ;
WO 2005/111025 A1
参考文献
Kori, Masakuni; Miki, Takashi; Nishimoto, Tomoyuki; Tozawa, Ryuichi
Patent: US2003/78251 A1, 2003 ;
