二(2-氯乙基)胺盐酸盐合成路线 （共 164 条）
反应条件
triethylamine in dichloromethane
Ambient temperature;
参考文献
Orji, Charles C.; Pinkus, A. G.
Organic Preparations and Procedures International, 1994 , vol. 26, # 6 p. 691 - 695
Title/Abstract Full Text Show Details
Orji, C. C.; Reibenspies, J. H.; Meyers, E. A.; Pinkus, A. G.
Phosphorus, Sulfur and Silicon and the Related Elements, 1994 , vol. 97, # 1-4 p. 9 - 16
反应条件
triethylamine in phosphorus(III) oxychloride; toluene
参考文献
Board of Regents, University of Texas System
Patent: US4841085 A1, 1989 ;
反应条件
potassium carbonate in acetone
4 h; Heating / reflux;
参考文献
Mitsubishi Pharma Corporation
Patent: EP1714961 A1, 2006 ;
Location in patent: Page/Page column 18 ;
反应条件
1: T=190°C; 0.0833333 h; Microwave irradiation;
2: With sodium hydrogencarbonate in water
参考文献
Isabel, Elise; Lachance, Nicolas; Leclerc, Jean-Philippe; Leger, Serge; Oballa, Renata M.; Powell, David; Ramtohul, Yeeman K.; Roy, Patrick; Tranmer, Geoffrey K.; Aspiotis, Renee; Li, Lianhai; Martins, Evelyn
Patent: US2011/301143 A1, 2011 ;
Location in patent: Page/Page column 65 ;
反应条件
(i) POCl3, CH2Cl2, (ii) /BRN= 3550356/, Et3N, (iii) NH3; Multistep reaction;
参考文献
Takamizawa,A. et al.
Journal of Medicinal Chemistry, 1975 , vol. 18, p. 376 - 383
反应条件
(i) POCl3, CH2Cl2, (ii) /BRN= 3550356/, Et3N, (iii) NH3; Multistep reaction;
参考文献
Takamizawa,A. et al.
Journal of Medicinal Chemistry, 1975 , vol. 18, p. 376 - 383
反应条件
sodium hydroxide; water
参考文献
I.G. Farbenind.
Patent: DE695216 , 1939 ;
DRP/DRBP Org.Chem.
Full Text Show Details
Jones; Wilson
Journal of the Chemical Society, 1949 , p. 550
反应条件
sodium carbonate in butan-1-ol
68 h; Heating/reflux;
参考文献
Abbott Laboratories
Patent: US6346622 B1, 2002 ;
Location in patent: Page column 7 ;
反应条件
potassium carbonate in diethylene glycol dimethyl ether
48 h; Heating;
参考文献
Glennon, Richard A.; Slusher, R. M.; Lyon, Robert A.; Titeler, Milt; McKenney, J. D.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2375 - 2380
反应条件
T=20 - 165°C; neat (no solvent);
参考文献
Konstantinova, Igor; Bukhryakov, Konstantin; Gezentsvey, Yuri; Krasavin, Mikhail
Letters in Organic Chemistry, 2011 , vol. 8, # 9 p. 628 - 630
