二(2-氯乙基)胺盐酸盐合成路线 （共 164 条）
反应条件
thionyl chloride in chloroform T=0 - 70°C;
参考文献
Huazhong University of Science and Technology; Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.; JIANG, Fengchao; ZHOU, Ping; CHEN, Jianguo; WANG, Yue; CAO, Baoshuai; YAN, Jia
Patent: EP2682390 A1, 2014 ;
Location in patent: Paragraph 0018; 0080 ;
反应条件
hydrogenchloride T=37°C; pH 1.2;
参考文献
Phosphorus, Sulfur and Silicon and Related Elements, , vol. 109, # 1-4 p. 473 - 476
反应条件
in various solvent(s) T=150°C;
参考文献
Liu, Kevin G.; Robichaud, Albert J.
Tetrahedron Letters, 2005 , vol. 46, # 46 p. 7921 - 7922
反应条件
in 2-(2-methoxy-ethoxy)-ethanol T=130°C; 24 h; Inert atmosphere;
参考文献
Weng, Zhiyong; Gao, Yanping; Zhang, Jiankang; Dong, Xiaowu; Liu, Tao
Journal of Chemical Research, 2011 , vol. 35, # 1 p. 43 - 46
反应条件
in various solvent(s) T=150°C;
参考文献
Liu, Kevin G.; Robichaud, Albert J.
Tetrahedron Letters, 2005 , vol. 46, # 46 p. 7921 - 7922
反应条件
(i) POCl3, CH2Cl2, (ii) /BRN= 3550356/, Et3N, (iii) NH3; Multistep reaction;
参考文献
Borch; Hoye; Swanson
Journal of Medicinal Chemistry, 1984 , vol. 27, # 4 p. 490 - 494
反应条件
sodium carbonate in butan-1-ol
参考文献
Xiao, Zhihui; Yuan, Mu; Zhang, Si; Wu, Jun; Qi, Shuhua; Li, Qingxin
Magnetic Resonance in Chemistry, 2005 , vol. 43, # 10 p. 869 - 872
反应条件
potassium carbonate in acetonitrile 8 h; Heating;
参考文献
Chang, Chih-Shiang; Lin, Ying-Ting; Shih, Shin-Ru; Lee, Chung-Chi; Lee, Yen-Chun; Tai, Chia-Liang; Tseng, Sung-Nien; Chern, Jyh-Haur
Journal of Medicinal Chemistry, 2005 , vol. 48, # 10 p. 3522 - 3535
反应条件
NaBH(OAc)3; triethanolamine in ethyl acetate; 1,2-dichloro-ethane
参考文献
Chen, Xiaoqi; Dai, Kang; Fan, Pingchen; Fu, Ying; Li, Leping; Mihalic, Jeffrey T.
Patent: US2004/142956 A1, 2004 ;
US 20040142956 A1
反应条件
1: in butan-1-ol 0.1 h; Microwave irradiation; 2: With sodium carbonate in butan-1-ol 0.316667 h; CoolingMicrowave irradiation;
参考文献
Huazhong University of Science and Technology; Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.; JIANG, Fengchao; ZHOU, Ping; CHEN, Jianguo; WANG, Yue; CAO, Baoshuai; YAN, Jia
Patent: EP2682390 A1, 2014 ;
Location in patent: Paragraph 0081 ;
