1-(十六烷氧基)-3-(三苯甲基氧基)-2-丙醇合成路线 （共 9 条）
反应条件
2: BF3 / methanol View Scheme
参考文献
Dobner; Rattay; Nuhn
Pharmazie, 1989 , vol. 44, # 1 p. 15 - 17
反应条件
2: BF3 / methanol View Scheme
参考文献
Dobner; Rattay; Nuhn
Pharmazie, 1989 , vol. 44, # 1 p. 15 - 17
参考文献
Mukaiyama, Teruaki; Tanaka, Shin; Asami, Masatoshi
Chemistry Letters, 1982 , p. 433 - 436
反应条件
in pyridine
T=50°C; 18 h;
参考文献
Huang, Zhaohua; Szoka Jr., Francis C.
Journal of the American Chemical Society, 2008 , vol. 130, # 46 p. 15702 - 15712
反应条件
1: 98 percent / 40percent aq. NaOH / 80 - 90 °C
2: 59 percent / 0.4percent aq. H2SO4 / propan-2-ol / Heating
3: 68 percent / pyridine / Ambient temperature
View Scheme
参考文献
Rattay, Bernd; Brezesinski, Gerald; Dobner, Bodo; Foerster, Guenter; Nuhn, Peter
Chemistry and Physics of Lipids, 1995 , vol. 75, # 1 p. 81 - 92
反应条件
1: 59 percent / 0.4percent aq. H2SO4 / propan-2-ol / Heating
2: 68 percent / pyridine / Ambient temperature
View Scheme
参考文献
Rattay, Bernd; Brezesinski, Gerald; Dobner, Bodo; Foerster, Guenter; Nuhn, Peter
Chemistry and Physics of Lipids, 1995 , vol. 75, # 1 p. 81 - 92
反应条件
1: 95 percent / SnCl4 / 70 °C
2: 98 percent / 40percent aq. NaOH / 80 - 90 °C
3: 59 percent / 0.4percent aq. H2SO4 / propan-2-ol / Heating
4: 68 percent / pyridine / Ambient temperature
View Scheme
参考文献
Rattay, Bernd; Brezesinski, Gerald; Dobner, Bodo; Foerster, Guenter; Nuhn, Peter
Chemistry and Physics of Lipids, 1995 , vol. 75, # 1 p. 81 - 92
反应条件
1: (i) NaNH2, toluene, (ii) /BRN= 2421038/, (iii) aq. AcOH
2: Py / 60 °C
View Scheme
参考文献
Anatol,J. et al.
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1964 , vol. 258, p. 6466 - 6469
反应条件
1: NaH / dimethylformamide
2: B(OH)3, (EtO)3B / Heating
3: 1.) Et3N, 2.) Et3N, water / 1.) diethyl ether, RT, 5 h, 2.) diethyl ether, reflux, 2 h
4: CHCl3; propan-2-ol; dimethylformamide / 12 h / 50 °C
5: H2 / 10percent Pd/C / ethanol / 12 h / 40 °C / 1034.3 Torr
6: Et3N / CHCl3 / 24 h / Heating
View Scheme
参考文献
Godfroid, Jean-Jacques; Broquet, Colette; Jouquey, Simone; Lebbar, Mariya; Heymans, Francoise; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 5 p. 792 - 797
