in benzene 72 h; Ambient temperature;

暂无反应条件数据

2,2-dimethyl-1-propanenitrile; titanium(III) chloride; copper in dichloromethane T=-23°C; aldol reaction; 3 h; Title compound not separated from byproducts;

2,2-dimethyl-1-propanenitrile; titanium(III) chloride; copper in dichloromethane T=-23°C; 3 h;

1: 47 percent / benzene / 72 h / Ambient temperature 2: n-BuLi / tetrahydrofuran; hexane / 0.08 h / 0 °C 3: tetrahydrofuran / 2 h / 0 °C 4: formic acid, Et3N / Pd2(dba)3CHCl3-P(OMe)3 / dioxane / 2 h / Ambient temperature; var. phosphorus ligands; var. times; var. concentrations of formic acid 5: 83 percent / H2 / 5percent Pd/C / methanol / 24 h / Ambient temperature 6: 11 percent / p-TsOH / tetrahydrofuran; H2O / 5 h / 50 °C View Scheme

tetrakis(triphenylphosphine) palladium(0); hexamethyl-silane T=160°C; 4 h;

acetic acid T=110°C;

2,2-dimethyl-1-propanenitrile; titanium(III) chloride; copper in dichloromethane T=-23°C; aldol reaction; 3 h; Title compound not separated from byproducts;

2,2-dimethyl-1-propanenitrile; titanium(III) chloride; copper in dichloromethane T=-23°C; 3 h;

2,2-dimethyl-1-propanenitrile; titanium(III) chloride; copper in dichloromethane T=-23°C; aldol reaction; 3 h; Title compound not separated from byproducts;