5’-O-（4,4’-二甲氧基三苯甲基）-2’-O-叔丁基二甲基硅基尿苷合成路线 （共 10 条）
反应条件
1H-tetrazole in acetonitrile T=20°C; 12 h;
参考文献
Sanghvi, Yogesh S.; Guo, Zhiqiang; Pfundheller, Henrik M.; Converso, Antonella
Organic Process Research and Development, 2000 , vol. 4, # 3 p. 175 - 181
反应条件
N-ethyl-N,N-diisopropylamine in tetrahydrofuran 18 h;
参考文献
Lyttle, Matthew H.; Wright, Peter B.; Sinha, Nanda D.; Bain, J. D.; Chamberlin, A. Richard
Journal of Organic Chemistry, 1991 , vol. 56, # 15 p. 4608 - 4615
反应条件
(2R,4S)-3-((R)-cyclopentyl(1-methyl-1H-imidazol-2-yl)methyl)-4-isopropyl-2-methoxyoxazolidine; N,N-diisopropylethylamine hydrochloride; N-ethyl-N,N-diisopropylamine in tetrahydrofuran
T=20°C; 24 h; Inert atmosphere; Reagent/catalystConcentration;
参考文献
Sun, Xixi; Lee, Hyelee; Lee, Sunggi; Tan, Kian L.
Nature Chemistry, 2013 , vol. 5, # 9 p. 790 - 795
反应条件
silver perchlorate; 1,4-diaza-bicyclo[2.2.2]octane in tetrahydrofuran
T=20°C; 2 h;
参考文献
Hakimelahi, Gholam H.; Proba, Zbigniew A.; Ogilvie, Kelvin K.
Tetrahedron Letters, 1981 , vol. 22, # 52 p. 5243 - 5246
参考文献
Serebryany; Beigelman
Nucleosides, nucleotides and nucleic acids, 2003 , vol. 22, # 5-8 p. 1007 - 1009
反应条件
1: imidazole / dimethylformamide / 60 °C
2: HF; pyridine / CH2Cl2 / 0 °C
3: 90 percent / pyridine / 0 °C
View Scheme
参考文献
Serebryany; Beigelman
Nucleosides, nucleotides and nucleic acids, 2003 , vol. 22, # 5-8 p. 1007 - 1009
反应条件
1: imidazole / dimethylformamide / 0 °C
2: imidazole / dimethylformamide / 60 °C
3: HF; pyridine / CH2Cl2 / 0 °C
4: 90 percent / pyridine / 0 °C
View Scheme
参考文献
Serebryany; Beigelman
Nucleosides, nucleotides and nucleic acids, 2003 , vol. 22, # 5-8 p. 1007 - 1009
反应条件
1: HF; pyridine / CH2Cl2 / 0 °C
2: 90 percent / pyridine / 0 °C
View Scheme
参考文献
Serebryany; Beigelman
Nucleosides, nucleotides and nucleic acids, 2003 , vol. 22, # 5-8 p. 1007 - 1009
反应条件
1: tetrazole; H20 / acetonitrile
2: glycerol; pyridine / 24 h / 20 °C
View Scheme
参考文献
Wang, Weimin; Song, Quanlai; Jones, Roger A.
Tetrahedron Letters, 1999 , vol. 40, # 51 p. 8971 - 8974
反应条件
pyridine in tetrahydrofuran
Ambient temperaturevar. ribonucleosides; Product distribution;
参考文献
Hakimelahi, Gholam H.; Proba, Zbigniew A.; Ogilvie, Kelvin K.
Tetrahedron Letters, 1981 , vol. 22, # 48 p. 4775 - 4778
