sodium peroxodisulphate; N-chloro-succinimide; trifluorormethanesulfonic acid; palladium diacetate in 1,2-dichloro-ethane T=60°C; Sealed tube; regioselective reaction;

N-chloro-succinimide; trifluorormethanesulfonic acid; palladium diacetate; 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate) in 1,2-dichloro-ethane T=90°C; 4 h; Sealed tube; regioselective reaction;

in various solvent(s) T=80°C; 2 h;

ethanol

1: thionyl chloride 2: ethanol View Scheme

1: N-chloro-succinimide; palladium diacetate; sodium peroxodisulphate; trifluorormethanesulfonic acid / 1,2-dichloro-ethane / 0.33 h / 90 °C / |Sealed tube 2: N-chloro-succinimide; palladium diacetate; trifluorormethanesulfonic acid; 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate) / 1,2-dichloro-ethane / 4 h / 90 °C / |Sealed tube View Scheme

n-butyllithium 1.) hexane,THF, -65 to -70 deg C, 45 min, 2.) THF, -70 deg C, 45 min; Yield given. Multistep reaction;

暂无反应条件数据

in acetonitrile T=30°C; Thermodynamic data;

T=120 - 130°C;