1: With acetic acid; thiourea in ethanol
16 h; Heating / reflux;
2: With hydrogenchloride in ethanol
16 h; Heating / reflux;
3: With sodium carbonate in water; ethyl acetate
参考文献
PFIZER LIMITED; PFIZER INC.
Patent: WO2004/108676 A1, 2004 ;
Location in patent: Page 143 ;
WO 2004/108676 A1
1: (3-{2-[(chloroacetyl)amino]-2-methylpropyl}phenyl)acetic acid With acetic acid; thiourea in ethanol
5 h; Heating / reflux;
2: ethanol With sulfuric acid in water
T=20°C; 1 h;