4-氯甲基-5-甲基-1,3-二氧杂环戊烯-2-酮合成路线 （共 22 条）
反应条件
N-chloro-succinimide in tetrachloromethane 80 h; Ambient temperatureIrradiation;
参考文献
Sakamoto; Ikeda; Tsukamoto
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 6 p. 2241 - 2248
参考文献
Ikeda, Shoji; Takebe, Yasushi; Hirayama, Ryoichi; Sakamoto, Fumio; Iuchi, Koji; Tsukamoto, Goro
Chemical and Pharmaceutical Bulletin, 1988 , vol. 36, # 1 p. 394 - 397
反应条件
chlorine in dichloromethane T=43 - 45°C; further solvents; Product distribution;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 36, # 1 p. 394 - 397
反应条件
potassium carbonate in N,N-dimethyl acetamide T=20 - 50°C; 4 h;
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 1 p. 323 - 338
反应条件
tetrabutylammomium bromide; sodium carbonate in acetone T=25 - 45°C; 4 h;
参考文献
WO2011/21224 A2, ;
Page/Page column 16-17 ;
反应条件
potassium carbonate in isobutyramide T=50°C; 5 h; Product distribution / selectivity;
参考文献
WO2007/47838 A2, ;
Page/Page column 21-22 ;
反应条件
1: trityl chloride; 4-(1-hydroxy-1-methylethyl)-2-propyl-1-{4-[2-(tetrazole-5-yl)phenyl]phenyl}methylimidazole-5-carboxylic acid With 1,8-diazabicyclo[5.4.0]undec-7-ene in water; acetone T=48 - 54°C; 2 h; Industry scale; 2: medoxomil chloride in water; acetone T=10 - 52°C; 6.5 h; Product distribution / selectivity;
参考文献
EP2426126 A1, ;
Page/Page column 8-9 ;
反应条件
Product distribution / selectivity;
参考文献
WO2007/47838 A2, ;
Page/Page column 24-26 ;
反应条件
triethylamine in dichloromethane 3 h; Ambient temperature;
参考文献
Kawai; Sakamoto; Taguchi; Kitamura; Sotomura; Tsukamoto
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 6 p. 1422 - 1425
反应条件
N-ethyl-N,N-diisopropylamine in N,N-dimethyl acetamide; ethyl acetate
参考文献
Sankyo Company, Limited
Patent: US5616599 A1, 1997 ;
US 5616599 A
