(6a,11b,16a,17a)-6,9-二氟-11,17-二羟基-16-甲基-3-氧代雄甾-1,4-二烯-17-硫代羧酸合成路线 （共 7 条）
反应条件
1: With 1,1'-carbonyldiimidazole in N,N-dimethyl-formamide T=20°C; 4 h; Inert atmosphere; 2: With hydrogen sulfide in N,N-dimethyl-formamide T=20°C; 4.5 h; Inert atmosphere;
参考文献
Zheng, Jin; Lai, Qinglin; Dai, Yiru; Zhao, Qingjie; Shen, Jingshan
Organic Preparations and Procedures International, 2008 , vol. 40, # 6 p. 566 - 566
反应条件
1: With sodium hydrogensulfide in isobutyramide T=0 - 20°C; 2 h; 2: in isobutyramide; water pH=3; Acidic conditions;
参考文献
WO2004/52912 A1, ;
Page 30-31 ;
反应条件
1: With triethylamine in dichloromethane T=-5°C; 2: With diethylamine in acetone 1 h; regioselective reaction;
参考文献
Organic Preparations and Procedures International, , vol. 40, # 6 p. 566 - 566
反应条件
triethylamine in dichloromethane; ethyl acetate; acetone
反应条件
1: Et3N / CH2Cl2 / 0.75 h 2: Et2NH / acetone / 1 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 22 p. 3717 - 3729
反应条件
1: Et3N / CH2Cl2 / 0.75 h 2: Et2NH / acetone / 1 h 3: 67.1 percent / KHCO3 / dimethylformamide / 0.25 h / 22 - 25 °C View Scheme
参考文献
Phillipps; Bailey; Bain; Borella; Buckton; Clark; Doherty; English; Fazakerley; Laing; Lane-Allman; Robinson; Sandford; Sharratt; Steeples; Stonehouse; Williamson
Journal of Medicinal Chemistry, 1994 , vol. 37, # 22 p. 3717 - 3729
反应条件
sodium hydrogencarbonate in N,N-dimethyl acetamide
40 h;
参考文献
Zheng, Jin; Lai, Qinglin; Dai, Yiru; Zhao, Qingjie; Shen, Jingshan
Organic Preparations and Procedures International, 2008 , vol. 40, # 6 p. 566 - 566
